Parallel synthesis of isatin-based serine protease inhibitors
The synthesis of N-functionalised isatins using parallel, solution synthesis is described. Functionalised polymers were employed as stoichiometric and catalytic reagents as well as purification media in the exercise, and the derivatives were screened against a panel of serine proteases; high percentage inhibition was observed in several cases. (C) 2000 Elsevier Science Ltd.
Shuttleworth, Stephen J.,Nasturica, Daniel,Gervais, Christian,Siddiqui, M. Arshad,Rando, Robert F.,Lee, Nola
p. 2501 - 2504
(2007/10/03)
N-alkylation of trimethylsilyl derivatives of isatin with halomethyl ketones
Trimethylsilyl derivative of isatin react with halomethyl ketones at the nitrogen atom in contrast to sodium salt of isatin, which reacts with these compounds at heterocyclic carbon atom. 1999 KluwerAcademic/Plenum Publishers.
Rekhter
p. 1165 - 1166
(2007/10/03)
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