Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are z-2-acylamino-3-monosubstituted propenoates.
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(2008/06/13)
Combination of thienamycin-type antibiotics with dipeptidase inhibitors
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(2008/06/13)
NUCLEOPHILIC SUBSTITUTION OF HALOGEN ATOMS IN gem-DICHLOROCYCLOPROPANES ACTIVATED BY ELECTRON-WITHDRAWING SUBSTITUENTS
The reactions of the methyl ester, N,N-dimethylamide, and nitrile of gem-dichlorocyclopropanecarboxylic acid with sodium methoxide and ethoxide take place with opening of the three-membered ring and lead to the correponding derivatives of succinic acid.Methyl and ethyl 3-formyl-2-methylpropionate were obtained from 2,2-dichloro-1-formyl-3-methylcyclopropane under analogous conditions.The reaction of sodium thiophenolate with the functionally substituted gem-dichlorocyclopropanes takes place with retention of the three-membered ring and the formation of the corresponding substituted diphenyl thioacetals of cyclopropanone.
Kulinkovich, O. G.,Tishchenko, I. G.,Romashin, Yu. N.
p. 213 - 216
(2007/10/02)
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