PROCESS FOR THE PREPARATION OF ENCLOMIPHENE CITRATE HAVING NEEDLE SHAPED CRYSTAL HABIT.
The present invention relates an improved and well reproducible process for the preparation of Enclomiphene citrate having needle shaped crystal habit, and moreover, it is also related to a solid form of Enclomiphene citrate.
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Paragraph 00206-00208; 00210; 00212; 00214; 00216
(2017/12/28)
CLOMIPHENE SYNTHESIS USING A SINGLE SOLVENT
The present invention provides a one-pot method for synthesizing clomiphene (a mixture of the isomers cis-clomiphene and trans-clomiphene) utilizing a single solvent. In a preferred embodiment, the single solvent is dichloromethane (DCM, also known as methylene chloride). The present invention provides an improved method for synthesizing clomiphene and purifying clomiphene isomers.
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(2017/04/04)
PROCESS FOR THE PREPARATION OF CLOMIPHENE
An improved process for the preparation of the active pharmaceutical ingredient Clomiphene and, in particular, trans-Clomiphene, using acetic acid or trifluoroacetic acid is disclosed.
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(2016/06/28)
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