cas 76-99-3, (+/-)-METHADONE | Articles data

Articles about 76-99-3Total 6 be found

Non-Racemic Mixtures of Various Ratios of D- and L-methadone and Methods of Treating Pain Using the Same
Non-racemic mixtures of D- and L-methadone containing a ratio ranging from about 2.5:1 to about 3.5:1 by weight of D-methadone to L-methadone, such as for example about 2.9:1 to about 3.1:1 by weight of D-methadone to L-methadone, or about 3:1 by weight of D-methadone to L-methadone, have been found to exhibit surprising and unexpected beneficial results in the treatment of neuropathic pain. Additionally, non-racemic mixtures of D- and L-methadone containing a ratio ranging from about 2.5:1 to about 3.5:1 by weight of D-methadone to L-methadone, about 2.9:1 to about 3.1:1 by weight of D-methadone to L-methadone, or for example about 3:1 by weight of D-methadone to L-methadone, in combination with other non-methadone opioids have been found to exhibit surprising and unexpected beneficial results in the treatment of mixed pain.
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Paragraph 0096; 0097; 0098

(2016/09/12)

"A NOVEL PROCESS FOR CHIRAL RESOLUTION OF HIGHLY PURE (6R)-6-(DIMETHYLAMINO)-4,4-DIPHENYL-3-HEPTANONE FROM RACEMIC METHADONE HYDROCHLORIDE"
The present invention discloses an improved process for preparing pure (dimethylarnino)-4,4-diphenyl-3-heptanone and its hydrochloride salt.
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Page/Page column 10

(2016/07/27)

(R)-6-(DIMETHYLAMINO)-4,4-DIPHENYLHEPTAN-3-ONE
(R)-6-(dimethylamino)-4,4-diphenylheptan-3-one and a process to produce thereof.
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Paragraph 0050-0067

(2014/12/09)

(R)-6-(DIMETHYLAMINO)-4,4-DIPHENYLHEPTAN-3-ONE
Methods for producing methadone and its resolution to produce (R)-6-dimethylamino-4,4-diphenylheptan-3-one ((R)- methadone). Such methods producing first the precursor compound 4-(dimethylamino)-2,2-diphenylpentanitrile. Oxidation of 4-(dimethylamino)-2,2-diphenylpentanitrile with ethyl magnesium halide and hydrolysis with of the complex to form 6-dimethylamino-4,4-diphenylheptan-3-one. Resolution to the (R)-isomer is effected by reaction with a bromocamphor salt. Once isolated the (R)-isomer is crystallised.
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Page/Page column 4; 5; 8

(2013/06/06)

Quaternary ammonium immunogenic conjugates and immunoassay reagents
This invention relates to novel quaternary ammonium immunogenic conjugates and reporter reagents useful for eliciting antibodies and in immunoassays. Processes for preparing such quaternary ammonium immunogenic conjugates and their use in immunoassays and in eliciting antibodies are also disclosed.
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(2008/06/13)

Radioimmunoassay for methadone
An improved immunoassay for methadone is disclosed. The subject radioimmunoassay utilizes a novel antigen, antibody and novel labelled methadone derivatives.
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(2008/06/13)