- Synthesis of 2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl methacrylates
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2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5yl methacrylates were synthesized for the first time by reaction of 5-hydroxyuracil derivatives with methacrylic anhydride. 5-Hydroxyuracil derivatives are involved in this reaction in the dioxo form. 2005 Pleiades Publishing, Inc.
- Krivonogov,Chernyshenko,Kozlova,Yakovleva,Spirikhin,Abdrakhmanov,Plechev,Sivkova,Battalov
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Read Online
- METHOD FOR PRODUCING (METH)ACRYLIC ACID ANHYDRIDE
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PROBLEM TO BE SOLVED: To provide an industrially useful method for producing a (meth)acrylic acid anhydride capable of producing a (meth)acrylic acid anhydride with high yield and high purity. SOLUTION: There is provided a method for producing a (meth)acrylic acid anhydride by reacting a (meth)acrylic acid alkali metal salt and sulfonyl chloride in an organic solvent. The (meth)acrylic acid alkali metal salt includes lithium (meth)acrylate, sodium (meth)acrylate, potassium (meth)acrylate or the like. Among these (meth)acrylic acid alkali metal salts, preferable are sodium acrylate, potassium acrylate, sodium methacrylate and potassium methacrylate in consideration of market feedability, reactivity and easiness of treatment after the reaction. In addition, the sulfonyl chloride includes benzenesulfonyl chloride, p-toluenesulfonyl chloride and methanesulfonyl chloride. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
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Paragraph 0032-0040
(2021/05/28)
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- Multicatalytic Transformation of (Meth)acrylic Acids: a One-Pot Approach to Biobased Poly(meth)acrylates
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Shifting from petrochemical feedstocks to renewable resources can address some of the environmental issues associated with petrochemical extraction and make plastics production sustainable. Therefore, there is a growing interest in selective methods for transforming abundant renewable feedstocks into monomers suitable for polymer production. Reported herein are one-pot catalytic systems, that are active, productive, and selective under mild conditions for the synthesis of copolymers from renewable materials. Each system allows for anhydride formation, alcohol acylation and/or acid esterification, as well as polymerization of the formed (meth)acrylates, providing direct access to a new library of unique poly(meth)acrylates.
- Fouilloux, Hugo,Placet, Vincent,Qiang, Wei,Robert, Carine,Thomas, Christophe M.
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supporting information
p. 19374 - 19382
(2021/07/21)
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- Method for preparing N-hydroxyethylmethacrylamide
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The invention discloses a method for preparing N-hydroxyethylmethacrylamide. Methacrylic anhydride moderately reacts with aminoethanol under low temperature. A generated byproduct methacrylic acid can be separated from a product through a distillation manner, and a production process is simple and feasible. The N-hydroxyethylmethacrylamide obtained by the method disclosed by the invention has high purity and high yield.
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Paragraph 0019; 0020; 0021
(2017/10/07)
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- METHOD FOR PRODUCING CARBOXYLIC ACID ANHYDRIDE AND METHOD FOR PRODUCING CARBOXYLIC ACID ESTER
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Provided is a production method whereby corresponding carboxylic acid anhydrides and carboxylic acid esters can be obtained at high yield from various carboxylic acids even without a solvent and near room temperature. A method for producing a carboxylic acid anhydride represented by formula (II), the method comprising reacting a compound represented by formula (I) and a carboxylic acid in the presence of a Group II metal compound having an ionic ligand containing an oxygen atom. A method for producing a carboxylic acid ester, the method comprising reacting a carboxylic acid anhydride produced by the aforementioned method and an alcohol. In formula (I), R1 represents a C1-20 hydrocarbon group. In formula (II), R2 represents a C1-20 hydrocarbon group.
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Paragraph 0075
(2017/04/18)
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- SYNTHESIS OF (METH) ACRYLIC ANHYDRIDE BY TRANSANHYDRIZATION
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The invention relates to a method for producing a (meth)acrylic anhydride A-C(═O)—O—(O═)C-A, comprising the following steps: a) a step of reacting an anhydride B—C(═O)—O—(O═)C—B with an acid A-COOH, resulting in the formation of mixed anhydride A-C(═O)—O—(O═)C—B and acid B—COOH; and b) a step of reacting the mixed anhydride with A-COOH, resulting in the (meth)acrylic anhydride. According to the invention, reaction steps (a) and (b) are carried out in the presence of hydrated triflic acid, and the anhydride A-C(═O)—O—(O═)C-A is isolated from the reaction medium produced in step (b) as follows: e1) heavy compounds having a volatility less than or equal to that of the anhydride A-C(═O)—O—(O═)C-A are separated from the reaction medium, said compounds including the anhydride and the hydrated triflic acid; e2) the anhydride is separated from the heavy compounds by difference in volatility.
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Paragraph 0100; 0101; 0102; 0103; 0104
(2016/12/01)
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- Synthesis of (meth)acrylic anhydride by transanhydrization
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The present invention relates to a process for preparing an anhydride of formula A-C(═O)—O—(O═)C-A, where A is —CR═CH2 and R is —H or —CH3, comprising: a) a step of reacting an anhydride B—C(═O)—O—(O═)C—B with an acid A-COOH, A being as defined above, wherein the step results in the formation of an anhydride A-C(═O)—O—(O═)C—B and of an acid B—COOH, A and B being such that said acid B—COOH is more volatile than said acid A-COOH, and b) a step of reacting said anhydride A-C(═O)—O—(O═)C—B with the acid A-COOH under conditions such that the amount of acid B—COOH is less than the amount of acid A-COOH, resulting in the formation of the anhydride A-C(═O)—O—(O═)C-A, in which said reaction steps are carried out in the presence of an acid catalyst which is more volatile than said anhydride A-C(═O)—O—(O═)C-A.
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Paragraph 0107-0108
(2016/05/19)
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- Α, β-unsaturated carboxylic acid manufacturing method
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PROBLEM TO BE SOLVED: To obtain high selectivity of α,β-unsaturated carboxylic acid which is an objective product, when producing the α,β-unsaturated carboxylic acid by subjecting alcohol, olefin or α,β-unsaturated aldehyde to liquid phase oxidation by molecular oxygen.SOLUTION: When producing the α,β-unsaturated carboxylic acid by subjecting alcohol, olefin or α,β-unsaturated aldehyde to liquid phase oxidation by molecular oxygen, a catalyst containing palladium is used, and after starting reaction of the liquid phase oxidation, supply of a molybdenum compound into a reaction system is started.
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Paragraph 0060; 0061; 0062; 0063; 0064; 0065
(2016/12/16)
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- Synthesis of (meth)acrylic anhydride by transanhydrization
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The present invention relates to a process for preparing an anhydride of formula A-C(═O)—O—(O═)C-A, where A is —CR═CH2 and R is —H or —CH3, comprising: a) a step of reacting an anhydride B—C(═O)—O—(O═)C—B with an acid A-COOH, A being as defined above, wherein the step results in the formation of an anhydride A-C(═O)—O—(O═)C—B and of an acid B—COOH, A and B being such that said acid B—COOH is more volatile than said acid A-COOH, and b) a step of reacting said anhydride A-C(═O)—O—(O═)C—B with the acid A-COOH under conditions such that the amount of acid B—COOH is less than the amount of acid A-COOH, resulting in the formation of the anhydride A-C(═O)—O—(O═)C-A, in which said reaction steps are carried out in the presence of an acid catalyst which is more volatile than said anhydride A-C(═O)—O—(O═)C-A.
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Paragraph 0107-0108
(2015/07/27)
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- Multi-scale promoting effects of lead for palladium catalyzed aerobic oxidative coupling of methylacrolein with methanol
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A highly efficient Pd2Pb8/alumina catalyst was prepared, which provided the highest turnover number (TON) of 302 for aerobic oxidative coupling of methylacrolein with methanol. The enhanced catalytic efficiency could be attributed to the multi-scale (micron, nano and atom scales) promoting effects of the pre-loaded Pb species. This journal is
- Han, Junxing,Zhang, Suojiang,Li, Yuchao,Yan, Ruiyi
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p. 2076 - 2080
(2015/04/14)
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- Synthesis of reactive azobenzene main-chain liquid crystalline polymers via michael addition polymerization and photomechanical effects of their supramolecular hydrogen-bonded fibers
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A new and efficient strategy for obtaining a series of reactive azobenzene (azo)-containing main-chain liquid crystalline polymers (LCPs) is described, which involves the first design and synthesis of acrylate-type azo monomers with different length of flexible spacers and an amino end-group (in its trifluoroacetate salt form) and their subsequent Michael addition polymerization under mild reaction conditions. The resulting polymers showed rather high thermal stability, relatively low glass transition temperatures, a broad temperature range of smectic C liquid crystalline phase, and reversible photoresponsive behavior. The presence of secondary amino groups in the backbones of these azo main-chain LCPs not only made them highly reactive precursors for various new functional linear and cross-linked azo LCPs but also led to the formation of hydrogen-bonding interactions among their polymer chains. Supramolecular hydrogen-bonding cross-linked LCP fibers were directly fabricated by using the simple melt spinning method, which proved to have a high order of mesogen along the fiber axis and exhibit good mechanical properties, fast and reversible photoinduced bending and unbending behaviors, and large photoinduced stress (240 kPa) at close to ambient temperature as well as excellent photodeformation fatigue resistance.
- Fang, Liangjing,Zhang, Hongtao,Li, Zidong,Zhang, Ying,Zhang, Yuying,Zhang, Huiqi
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p. 7650 - 7660
(2013/10/22)
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- Synthesis of unsaturated diesters of primary, secondary and tertiary diols derived from dimethyl (+)-tartrate and galactaric acid
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The preparation of symmetrical unsaturated diesters of dioe first was the reaction of mixed anhydrides, obtained from α,β-unsaturated acids and benzoyl chloride, with diols 3 (primary), 5 (secondary), and 7 (primary), i.e., Yamaguchi-SantaLucia's method, however only the symmetrical diacrylates of diols 5 and 7 were obtained quantitatively. In the other ten cases studied the reactions led to mixtures of symmetrical and unsymmetrical diesters that were difficult to separate. The mixed anhydrides did not react with the tertiary diols 4 (TADDOL) and 8. The average yield obtained in desired symmetrical diesters in the 12 cases studied was 54 %. The acylation of the diols with the anhydrides of the unsaturated acids, was found to be an excellent method, leading to the symmetrical unsaturated diesters of diols 3, 5, 7 as the only products of reaction, in an average yield of 83 %. Unfortunately, the method could not be applied to diesters derived from the tertiary diols 4 (TADDOL) and 8. The third method studied was the reaction between the alkoxides prepared with solutions of nBuLi in ether with the unsaturated acid chlorides at-50 °C, i.e., the Kaiser-Woodruff protocol. This was found to be the best of the three methods tested. The method was applied with success to the synthesis of the desired unsaturated diesters derived from diols 3-5, 7, and 8. The average yield of the 19 cases studied was 78 %. Copyright
- Scoccia, Jimena,Gerbino, Dario C.,Terraza, Victor F.,Zuniga, Adriana E.,Podesta, Julio C.
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p. 4418 - 4426
(2013/07/26)
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- Azobenzene-containing molecularly imprinted polymer microspheres with photoresponsive template binding properties
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The first successful preparation of azobenzene (azo)-containing molecularly imprinted polymer (MIP) microspheres with photoresponsive template binding properties is described. A methacrylate azo functional monomer with a pyridine group was used for this purpose, and its good solubility in acetonitrile allowed the implementation of molecular imprinting via precipitation polymerization, leading to azo-containing MIP microspheres (number-average diameter = 1.33 μm, polydispersity index = 1.15) with obvious molecular imprinting effects towards the template 2,4-dichlorophenoxyacetic acid (2,4-D), rather fast template rebinding kinetics, and appreciable selectivity over structurally related compounds. The binding association constant Ka and apparent maximum number Nmax for high-affinity sites of the imprinted polymer in the dark environment were determined by Scatchard analysis to be 2.3 × 104 M-1 and 10.0 μmol g-1, respectively. Most importantly, the binding affinity of the imprinted sites in azo-containing MIP microspheres was found to be photoresponsive towards the template, which decreased upon UV light irradiation (as revealed by the resulting lower K a value for high-affinity sites and reduced specific bindings), whereas it could be recovered during the subsequent thermal (or visible light-induced) back-isomerization. Furthermore, this photoregulation process proved to be highly repeatable under photoswitching conditions. The Royal Society of Chemistry.
- Fang, Liangjing,Chen, Sujing,Zhang, Ying,Zhang, Huiqi
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experimental part
p. 2320 - 2329
(2011/10/12)
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- METHOD FOR PRODUCING (METH)ACRYLIC ANHYDRIDE, METHOD FOR STORING (METH)ACRYLIC ANHYDRIDE, AND METHOD FOR PRODUCING (METH)ACRYLATE
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It is an object of the present invention to provide a method for producing (meth)acrylic anhydride that provides high yield and high efficiency and can suppress side reactions, in a method for reacting (meth)acrylic acid with a fatty acid anhydride to produce (meth)acrylic anhydride. The method for producing (meth)acrylic anhydride according to the present invention is a method for producing (meth)acrylic anhydride, including reacting a fatty acid anhydride with (meth)acrylic acid to produce (meth)acrylic anhydride, while extracting a fatty acid produced as a by-product, wherein the reaction is performed, while adjustment is performed so that a molar ratio of the (meth)acrylic acid to the (meth)acrylic anhydride in a reaction liquid is 0.3 or more.
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Page/Page column 12
(2011/06/24)
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- METHOD FOR PRODUCING A (METH)ACRYLATE
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Disclosed is a method for producing a (meth)acrylate ester wherein a high purity (meth)acrylate ester is obtained with a high yield, with a reduced loss of (meth)acrylic acid anhydride. In the method, (meth)acrylic acid is recovered with a high yield, and the (meth)acrylate ester is purified easily. Specifically disclosed is a method for producing a (meth)acrylate ester which comprises: (1) a step of producing (meth)acrylic acid anhydride by reacting a specific fatty acid anhydride and (meth)acrylic acid, while removing a by-produced fatty acid; (2) a step of obtaining a (meth)acrylate ester by reacting an alcohol and unpurified (meth)acrylic acid anhydride obtained in step (1) preferably at a temperature not less than 90° C.; and (3) a step of recovering (meth)acrylic acid by distillation preferably at a temperature not less than 90° C. The method may also comprise a step of heating or distilling the reaction liquid obtained in step (2) at a temperature not less than 90° C.
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Page/Page column 11
(2011/12/14)
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- METHOD FOR PRODUCING (METH)ACRYLIC ACID ANHYDRIDE, METHOD FOR STORING (METH)ACRYLIC ACID ANHYDRIDE, AND METHOD FOR PRODUCING (METH)ACRYLATE ESTER
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It is an object of the present invention to provide a method for producing (meth)acrylic anhydride that provides high yield and high efficiency and can suppress side reactions, in a method for reacting (meth)acrylic acid with a fatty acid anhydride to produce (meth)acrylic anhydride. The method for producing (meth)acrylic anhydride according to the present invention is a method for producing (meth)acrylic anhydride, including reacting a fatty acid anhydride with (meth)acrylic acid to produce (meth)acrylic anhydride, while extracting a fatty acid produced as a by-product, wherein the reaction is performed, while adjustment is performed so that a molar ratio of the (meth)acrylic acid to the (meth)acrylic anhydride in a reaction liquid is 0.3 or more.
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Page/Page column 15-18
(2011/04/25)
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- METHOD FOR PRODUCING ALPHA, BETA-UNSATURATED CALBOXYLIC ACID
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Disclosed is a method for producing an α, β-unsaturated carboxylic acid from an olefin or an α, β-unsaturated aldehyde, while suppressing dissolution of a silica carrier, which is a carrier for a silica-supported noble metal-containing catalyst, in a water-containing solvent. Specifically disclosed is a method for producing an α, β-unsaturated carboxylic acid through oxidation of an olefin or an α, β-unsaturated aldehyde in a water-containing solvent in the presence of a silica-supported noble metal-containing catalyst in a reactor, in which at least one of silicic acid and ions thereof is supplied into the reactor.
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Page/Page column 4-5
(2010/06/16)
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- METHOD FOR PREPARING (METH)ACRYLIC ANHYDRIDE
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The present invention relates to an improved method for preparing (meth)acrylic anhydride (A(M)A2O) by transanhydrification between (meth)acrylic acid and acetic anhydride in the presence of at least one polymerization inhibitor, in which reaction to the point of partial conversion of the reagents is carried out, followed by continuous distillation. With the method according to the invention, it is possible to produce I1A(M)A2O of very high purity under improved productivity conditions compared to existing methods while eliminating problems of reactor fouling.
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Page/Page column 3; 4
(2010/12/29)
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- METHOD FOR THE CONTINUOUS PRODUCTION OF UNSATURATED CARBOXYLIC ACID ANHYDRIDES
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Process for continuously preparing unsaturated carboxylic anhydrides of the general formula I [in-line-formulae]R—C(O)—O—C(O)—R??(I)[/in-line-formulae] in which R is an unsaturated organic radical having 2 to 12 carbon atoms by transanhydridization of an aliphatic carboxylic anhydride with a carboxylic acid of the general formula II [in-line-formulae]R—COOH??(II)[/in-line-formulae] in which R is as defined above in a rectification column having an upper, middle and lower region, characterized in that f) an inert boiling oil is initially charged in the bottom of the column,g) the reactants are fed into a reaction region in stoichiometric ratios,h) the carboxylic acid formed as the by-product is withdrawn at the top of the column,i) the unconverted reactants are recycled into the reaction region andj) the product of the formula I is obtained via a side draw, preferably between the middle and lower column region.
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Page/Page column 3
(2009/10/30)
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- METHOD FOR THE PRODUCTION OF (METH)ACRYLIC ANHYDRIDE
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The present invention relates to an improved method for manufacturing (meth)acrylic anhydride by transanhydrization between (meth)acrylic acid and acetic anhydride, in the presence of air and in the presence of at least one polymerization inhibitor, characterized in that the polymerization inhibitor is chosen from the group formed from (a) metal salts of thiocarbamic or dithiocarbamic acid and their mixtures with a phenolic derivative or phenothiazine and its derivatives, and (b) N-oxyl compounds as a mixture with 2,6-di-tert-butyl-4-methylphenol taken alone or in the presence of 2,4-dimethyl-6-tert-butylphenol.
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Page/Page column 2-3
(2009/09/28)
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- PROCESS FOR PRODUCING ALPHA, BETA-UNSATURATED CARBOXYLIC ACID
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Disclosed is a method for enhancing a yield of an α,β-unsaturated carboxylic acid obtained by liquid-phase oxidation reaction of an olefin or an α,β-unsaturated aldehyde. In particular, there is provided a method for producing an α,β-unsaturated carboxylic acid, wherein the method includes the step of carrying out oxidation reaction of an olefin or an α,β-unsaturated aldehyde in a liquid phase to obtain a reaction mixture containing an α,β-unsaturated carboxylic acid and an α,β-unsaturated carboxylic acid anhydride and the step of bringing the α,β-unsaturated carboxylic acid anhydride into contact with an alcohol or water to obtain an α,β-unsaturated carboxylic acid resulting from decomposition of the α,β-unsaturated carboxylic acid anhydride.
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Page/Page column 8-9
(2009/07/25)
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- METHOD FOR PURIFYING POLYMERIZABLE COMPOUNDS
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Process for distillatively purifying polymerizable compounds using a high-boiling, inert, thermally long-term-stable substance as a boiling oil, characterized in that the boiling oil is disposed in the bottom of a rectification column.
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Page/Page column 2
(2009/07/17)
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- Method for producing hydroxyphenyl acrylate monomers and polymers
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New syntheses of phenolic acrylate monomers are provided as well as polymers comprising such phenolic acrylate monomers. Preferred polymers of the invention are useful as a resin component of chemically-amplified positive-acting resists.
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Page/Page column 6
(2008/12/08)
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- PROCESS FOR PRODUCING ACID ANHYDRIDE
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According to the present invention there is provided a process for producing an acid anhydride by reacting a carboxylic acid, preferably a carboxylic acid having a polymerizable group, with a sulfonyl halide compound in the presence of a tertiary amine or in the presence of a tertiary amine and an inorganic base, wherein the tertiary amine or the tertiary amine and the inorganic base are used in an amount of 0.9 to 1.2 equivalents relative to the acid generated from the sulfonyl halide compound.
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- PROCESS FOR PRODUCING (METH)ACRYLIC ANHYDRIDE AND PROCESS FOR PRODUCING (METH) ACRYLIC ESTER
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(Meth)acrylic acid is reacted with a fatty acid anhydride and the resultant reaction mixture is neutralized and washed with an aqueous alkaline solution having a pH of 7.5 to 13.5. Thus, high-purity (meth)acrylic anhydride can be industrially advantageously produced while avoiding polymerization. This (meth)acrylic anhydride is reacted with a secondary or tertiary alcohol in the presence of a basic compound which in 25° C. water has an acidity (pKa) of 11 or lower. Thus, a high-purity (meth)acrylic ester can be produced in high yield.
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- Method for making mixed high purity (meth)acrylic anhydrides
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The invention concerns a method consisting in making a mixed (meth)acrylic anhydride of formula (I) by reacting an alkaline (meth)acrylate of formula (II) and a chloroformate of formula (III), carrying out said reaction in an aqueous medium and in the absence of amines, the mol ratio chloroformate (III)/alkaline (meth)acrylate (II) being at least equal to 1.15. R1represents H or CH3; R2represents an alkyl, alkenyl, aryl, alkaryl or aralkyl residue; and M is an alkaline metal.
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Page column 5-7
(2008/06/13)
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- A NEW SYNTHESIS OF CARBOXYLIC AND CARBONIC ACID ANHYDRIDES USING PHASE TRANSFER REACTIONS
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Acyl chlorides and alkylchloroformates smoothly reacted with one molar equivalent of sodium hydroxide, using liquid-liquid phase transfer conditions to afford high yields of the corresponding symmetrical carboxylic and carbonic hemiester anhydrides.Unstable anhydrides such as 4-nitrobenzoic, 2-furoic and methacrylic anhydrides, which are otherwise difficult to obtain, were easily prepared by this method.The reaction mechanism does not seem to involve intermediate hydrolysis of half the acid chloride into the corresponding sodium carboxylate.
- Plusquellec, Daniel,Roulleau, Fabienne,Lefeuvre, Martine,Brown, Eric
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p. 2471 - 2476
(2007/10/02)
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- PHASE MANAGED ORGANIC SYNTHESIS 2. A NEW POLYMER ASSISTED SYNTHESIS OF ACID ANHYDRIDES.
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A solid-phase copolymer of 4-vinylpyridine is shown to be a highly effective reagent/catalyst for the synthesis of acid anhydrides from mixtures containing equimolar quantities of carboxylic acid and acid chlorides.The process may be carried out in batch or column mode.
- Fife, Wilmer K.,Zhang, Zhi-dong
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p. 4933 - 4936
(2007/10/02)
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- PHASE MANAGED ORGANIC SYNTHESIS 3. SYMMETRICAL ANHYDRIDES FROM CARBOXYLIC ACIDS VIA POLYMER ASSISTED REACTION.
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Symmetrical anhydrides are produced quickly and in high yield by treating mixtures of a carboxylic acid and one-half equivalent thionyl chloride in dichloromethane with a solid-state copolymer of 4-vinylpyridine.This conversion is accomplished equally well in batch or column mode.
- Fife, Wilmer K.,Zhang, Zhi-dong
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p. 4937 - 4940
(2007/10/02)
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- UNE METHODE SIMPLE ET RAPIDE DE PREPARATION DES ANHYDRIDES D'ACIDES CARBOXYLIQUES A PARTIR DE LEURS CHLORURES D'ACIDES, AVEC CATALYSE PAR TRANSFERT DE PHASE
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Symmetrical anhydrides of carboxylic acids were readily obtained, and in high yields under phase transfer conditions, i.e. by reacting the appropriate acid chloride in toluene solution (containing 0.1 eq. of n-Bu4N+ Cl-), with 20percent aqueous sodium hydroxide solution.
- Roulleau, Fabienne,Plusquellec, Daniel,Brown, Eric
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p. 4195 - 4196
(2007/10/02)
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- Enzymes immobilisees. 14 : Immobilisation de la chymotrypsine prealablement protegee par un inhibiteur macromoleculaire synthetique
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A new water-soluble acrylic copolymer 13, with spacer-arms bearing N-(4-phenylbutyl)amido groups, was sythesized and was efficiently used to protect α-chymotrypsin during immobilization of the latter on Acaprosuc, an insoluble cross-linked polyacrylic gel whose side-chains end with reactive N-siccinimidyl ester groups.The insoluble chymotrypsin/Acaprosuc conjugates prepared in the presence of the polyinhibitor 13 were twice as active towards heamoglobin, and 2 to 4 times as active towards ATEE, as the corresponding conjugates prepared in the absence of the polyinhibitor 13.These results represent a generalization of the enzyme protection/immobilization/deprotection method which was developed in our laboratory some years ago in the particular case of trypsin.
- Brown, Eric,Loriot, Michel
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p. 481 - 489
(2007/10/02)
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