76017-87-3 Usage
Uses
Used in Pharmaceutical Industry:
2-(1-Cyanoethyl)indole is used as a synthetic intermediate for the development of pharmaceutical actives. Its unique structure allows for the creation of a wide range of compounds with potential therapeutic applications, making it a valuable asset in the pharmaceutical industry.
Used in Chemical Industry:
In the chemical industry, 2-(1-Cyanoethyl)indole is utilized as an intermediate for the production of various fine chemicals. Its versatility in chemical reactions enables the synthesis of a diverse array of specialty chemicals, which can be used in different applications, such as agrochemicals, dyes, and other industrial products.
Check Digit Verification of cas no
The CAS Registry Mumber 76017-87-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,0,1 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 76017-87:
(7*7)+(6*6)+(5*0)+(4*1)+(3*7)+(2*8)+(1*7)=133
133 % 10 = 3
So 76017-87-3 is a valid CAS Registry Number.
76017-87-3Relevant articles and documents
New 5-HT3 (serotonin-3) receptor antagonists, II. Synthesis and structure-activity relationships of pyrimido[1,6-a]indoles.
Kato,Nishino,Ito,Yamakuni,Takasugi
, p. 2556 - 2564 (2007/10/02)
A series of pyrimido[1,6-alpha]indol-1(2H)-ones was prepared and evaluated for 5-HT3 receptor antagonist activity. The compounds in this series were regarded as bioisosters of the pyrido[1,2-alpha]indol-6(7H)-ones previously reported. High potency was found for compounds having 5-methyl substituents on both the pyrimido[1,6-alpha]indole ring and the imidazole ring. Optimized members of this series, 8b and (+)-26a, were potent 5-HT3 receptor antagonists as determined by measuring inhibition of the Bezold-Jarisch reflex in anesthetized rats (ED50 0.6 and 0.8 microgram/kg i.v., respectively), being equipotent to or more potent than FK 1052 (1) in the previous paper and 20- to 30-fold more potent than ondansetron (2).
