Construction of trifluoromethylated quaternary stereocenters: Via p -quinone methides
Development of a new synthetic method for the construction of quaternary centers with a trifluoromethyl group was realized by way of 1,6-addition of various nucleophiles including active methylene compounds to highly reactive δ-trifluoromethylated p-quinone methides generated in situ from the corresponding tertiary carbonates with a catalytic amount of an appropriate base.
Poly(ethylene glycol)-supported ααα-trifluoroacetophenone in dioxirane mediated alkene epoxidation reactions
Poly(ethylene glycol) (PEG) was used for the immobilization of ααα-trifluoroacetophenone and the utility of this supported ketone has been examined in dioxirane mediated epoxidation of alkenes. The PEG-ketone reagent was found to be an effective homogeneous catalyst for the epoxidation of a variety of alkenes in the presence of Oxone A? and was readily recovered from the reaction mixtures and reused.
Kan, Jovi Tze Wai,Toy, Patrick
p. 6357 - 6359
(2007/10/03)
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