One-pot synthesis of oxime ethers from benzaldehyde or acetophenone, hydroxylamine salt, potassium hydroxide, and alkyl halides
Oxime ethers were synthesized in one-pot reaction from benzaldehyde or acetophenone, hydroxylamine hydrogen chloride, alkyl halides and KOH in aqueous DMSO. The reactions were completed in 15-50 min with yields in 80-96%.
Li, Chunbao,Zhang, Hang,Cui, Yi,Zhang, Shuanming,Zhao, Zheyuan,Choi, Michael C. K.,Chan, Albert S. C.
p. 543 - 546
(2007/10/03)
THE PREPARATION OF OXIME ETHERS UNDER PHASE TRANSFER CONDITION
O-Butyloximes, O-allyloximes, O-2-chloroethyloximes, and O,O'-methylenedioximes were prepared from the corresponding oximes and halides under the phase transfer condition using sodium hydroxide and tetrabutylammonium bromide.