Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasitics
There is an urgent need for new drugs to treat leishmaniasis and Chagas disease. One important drug target in these organisms is sterol biosynthesis. In these organisms the main endogenous sterols are ergosta- and stigmata-like compounds in contrast to th
Lorente, Silvia Orenes,Jimenez, Carmen Jimenez,Gros, Ludovic,Yardley, Vanessa,De Luca-Fradley, Kate,Croft, Simon L.,Urbina, Julio A.,Ruiz-Perez, Luis M.,Pacanowska, Dolores Gonzalez,Gilbert, Ian H.
p. 5435 - 5453
(2007/10/03)
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