Chemoselective deprotection of aryl tert-butyldimethylsilyl ethers promoted by phosphates
A facile protocol to the chemoselective deprotection of aryl t-butyldimethylsilyl (TBDMS) ethers using Na3PO4 ? 12H2O as promoter is described. From aryl TBDMS ethers to the corresponding phenols, the TBDMS group could be cleaved in the presence of 0.5 equivalent of Na3PO4 ? 12H2O in dimethylformamide at room temperature with good to excellent yields in the presence of other common protecting and functional groups. K3PO 4 ? 3H2O was also found to be useful for the selective deprotection reaction. This is, to our knowledge, the first report on chemoselective deprotection of aryl TBDMS ethers using phosphates. Taylor & Francis Group, LLC.
Conversion of alcohols to thiols via tosylate intermediates
High yielding syntheses of mercapto terminated mono-disperse dimer, trimer, and tetramer ethyleneoxide oligomers and of p-hydroxyphenethyl thiol via an alcohol-tosylate-thiol route are reported. Comparisons are made with the more conventional alcohol-bromide-thiol route.
Snow, Arthur W.,Foos, Edward E.
p. 509 - 512
(2007/10/03)
Reagents for labeling SH groups, process for the preparation of them and method for labeling with them
Disclosed are SH-labeling reagents containing acridine compounds represented by the following formula (I): whereinA represents the following group:—(CH2)m1—or—(CH2)m2—Q—(CH2)n—in which Q re
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(2008/06/13)
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