- Design, synthesis and antimalarial activity of some new 2-hydroxy-1,4-naphthoquinone-4-hydroxyaniline hybrid mannich bases
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In this study, some novel 2-hydroxy-1,4-naphthoquinone-4-hydroxyaniline hybrid Mannich bases were designed, synthesized and evaluated for in vitro antimalarial activity. The design strategy of novel hybrid molecules involves fusion between the pharmacopho
- Sharma, Dipshikha,Chetia, Dipak,Rudrapal, Mithun
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p. 782 - 788
(2016/03/01)
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- Microwave-induced Mannich reaction - Synthesis of some Mannich derivatives of p-aminophenol
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Mono and bis substituted dialkylamino alkyl-p-aminophenol 3 are prepared by treating paracetamol 1 with formaldehyde and appropriate secondary amines followed by deacetylation using 6 M HCI in unmodified domestic microwave oven in unsealed borosil vessels
- Mahesh,Perumal, R. Venkatesha
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p. 1012 - 1014
(2007/10/03)
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- Pyrazole compounds
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Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.
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- Synthesis of new arylaminoquinoxalines and their antimalarial activity in mice
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2-Arylaminoquinoxalines were prepared by the condensation of 2-chloroquinoxaline with the appropriate Mannich bases in the presence of HCI. To synthesize the Mannich bases, 4-acetamidophenol was reacted with formaldehyde and dialkylamine to yield 3-[(dial
- Rangisetty,Gupta,Prasad,Srinivas,Sridhar,Parimoo,Veeranjaneyulu
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p. 1409 - 1413
(2007/10/03)
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