- HETEROCYCLIC DERIVATIVES OF PURINES. 5. NUCLEOPHILIC SUBSTITUTION IN SERIES OF IMIDAZOPURINE DERIVATIVES
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The chlorination of 1,8-dimethyl-7-phenylimidazoxanthine with an equimolar amount of PCl5 in POCl3 leads to 2,4-dichloro-8-methyl-7-phenylimidazopurine.The possibility of substitution of the halogen atoms in reactions with nucleophilic reage
- Garmash, S. N.,Priimenko, B. A.,Klyuev N. A.,Romanenko, N. I.,Sheinkman, A. K.
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p. 330 - 334
(2007/10/02)
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- HETEROCYCLIC DERIVATIVES OF PURINES. 3. SYNTHESIS AND MASS SPECTROMETRIC STUDY OF IMIDAZOPURINE
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A mixture containing 65percent 1-methyl-2-phenyl-5,7-dichloro- and 35percent 1-methyl-2-phenyl-3,5,7-trichloroimidazopurine (the percentages of the components were established by means of chromatographic mass-spectrometric analysis) was obtained by refluxing 1,8-dimethyl-2-phenylimidazoxanthine in POCl3 in the presence of excess PCl5.Reduction of this mixture with concentrated HCl in the presence of red phosphorus leads to 1-methyl-2-phenylimidazopurine, while heating with piperidine gives a mixture consisting of 55percent 1-methyl-2-phenyl-6-piperidino-8-chloroimidazopurine and 45percent 1-methyl-2-phenyl-3,8-dichloro-6-piperidinoimidazopurine.The IR, PMR, and mass spectra of the compounds obtained are discussed.
- Priimenko, B. A.,Garmash, S. N.,Romanenko, N. I.,Klyuev, N. A.,Sheinkman, A. K.
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p. 877 - 881
(2007/10/02)
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