- PROCESS FOR THE PREPARATION OF TRANS 4-AMINO-CYCLOHEXYL ACETIC ACID ETHYL ESTER HCL
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The invention relates to a process for the preparation of trans 4-amino-cyclohexil ethyl acetate HCl wherein d) hydrogenating 4-nitrophenyl acetic acid in a protic solvent at a temperature between 40-500C in the presence of Pd/C under 0.1-0.6 bar overpres
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Page/Page column 4
(2010/08/05)
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- BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS
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The present invention relates to compounds of formula (I) wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general formula (I) have high affinity for the dopamine D3 and serotonin (5-Hydroxytryptamine; 5-HT) 5-HT2A receptors and are effective in the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.
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Page/Page column 10
(2009/03/07)
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- Aminopyrimidines with high affinity for both serotonin and dopamine receptors
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A series of {4-[2-(4-arylpiperazin-1-yl)alkyl]cyclohexyl}pyrimidin-2- ylamines was prepared and found to have receptor binding affinity for D2 and D3 dopamine (DA) receptors and serotonin 5-HT1A receptors. The structural contributions to D2/D3 and 5-HT1A
- Wustrow, David,Belliotti, Thomas,Glase, Shelly,Kesten, Suzanne Ross,Johnson, Don,Colbry, Norman,Rubin, Ronald,Blackburn, Anthony,Akunne, Hyacinth,Corbin, Ann,Duff Davis,Georgic, Lynn,Whetzel, Steven,Zoski, Kim,Heffner, Thomas,Pugsley, Thomas,Wise, Lawrence
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p. 760 - 771
(2007/10/03)
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