ORGANOMETALLIC INDUCED SELF-CONDENSATION OF CARBOXAMIDES
N,N-Disubstituted carboxamides containing α-hydrogen atoms undergo self-condensation reaction simply on treatment with Grignard reagents or n-BuLi in THF at room temp.The reaction is considerably influenced by steric hindrance at the α-carbon and the condensing agent utilized.A possible Claisen-type mechanism is also reported.
Babudri, F.,Ciminale, F.,Nunno, L. Di,Florio, S.
p. 557 - 561
(2007/10/02)
REACTION BETWEEN N-ACYL-2,3-DIHYDROBENZO-1,4-THIAZINE AND N-ACYLPHENOTIAZINE WITH ORGANOMETALLIC REAGENTS
The title N-acyl-derivatives react with n-BuLi and Grignard reagents leading to products, which, formally, can be considered as derived from a Claisen-type condensation reaction.