Synthesis of 1,1-dioxopenicillanoyloxymethyl 6-[D-α-(benzylideneaminophenylacetamido)]penicillanate and analogs. New intermediates in the preparation of sultamicillin
The synthesis of benzylidene imines of sultamicillin and analogs 1 is described. These new compounds showed high stability and were prepared under very mild conditions and high yields. Furthermore, they are convenient starting materials for the preparation of sultamicillin 5 (important prodrug of ampicillin and sulbactam) as its base form, by deprotection of the amino group with Girard reagents.
Del Pozo, Carlos,Alonso, Eduardo,López-Ortiz, Fernando,Fernández-Marí, Félix,Bayod, Miguel,González, Javier
p. 6209 - 6214
(2007/10/03)
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