- Preparation method of royal jelly acid
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The invention discloses a preparation method of royal jelly acid, and belongs to the field of chemical synthesis. The preparation method comprises the following steps: taking 1, 10-decanediol as a rawmaterial, taking water as a solvent, and under the action of potassium persulfate and tetraalkyl ammonium bromide, preparing a 2-bromodecalactone (II) compound, wherein the reaction adopts an one-potmethod to carry out three step reactions of oxidation, lactonization and alpha-H bromination respectively, and has relatively high selectivity and yield; and carrying out hydrolysis and elimination reaction on the 2-bromodecalactone (II) compound, and finally carrying out acidifying to obtain a royal jelly acid target product; the purity of a crude product can reach 95%, and the purity of the product reaches more than 99% after recrystallization. According to the method, the royal jelly acid is prepared by adopting two steps, and the preparation method has the advantages of short route and simplicity and convenience in operation, is easy for industrial production, and is a method for synthesizing the royal jelly acid very economically and simply.
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Paragraph 0026; 0029; 0031; 0033; 0034; 0036-0037; 0039-0040
(2019/07/01)
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- NOVEL CERAMIDE ANALOGUES, PROCESSES FOR PREPARING SAME AND USES THEREOF
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Compounds, ceramide analogues, having a cyclic structure derived from cyclopropane, cyclobutane or cyclopentane, the ring bearing two chains consisting of an amide function. Each amide function is attached to the ring by the nitrogen atom of the function and carries a hydrocarbon chain derived from a fatty acid. The amide functions can be cis or trans relative to one another. Processes for the preparation of these novel compounds as well as pharmaceutical and/or cosmetic compositions containing them.
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- Novel Method for Preparing Unsaturated Fatty Hydroxyacids
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The invention concerns a method for preparing a compound of formula (I), wherein: R3 and R1 represent in particular H and n is greater than 4, said preparation method including performing a Wittig-Horner reaction with a phosphonate on a lactol, so as to obtain a hydroxyester and, optionally a saponification reaction of said hydroxyester.
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Page/Page column 11
(2008/12/08)
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- WITTIG-HORNER REACTION IN HETEROGENOUS MEDIA VII. A NEW STRATEGY FOR THE TOTAL SYNTHESIS OF THE ROYAL JELLY ACID AND THE QUEEN SUBSTANCE OF HONEY-BEE
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A new general scheme for the preparation of Royal Jelly acid and Queen Substance of honey-bee, including, as the key steps, copper I catalyzed addition of functional (protected alcohol and ketone) Grignard reagents to acrolein diethylacetal, and the Wittig-Horner reaction of unprotected 8-hydroxyoctanal and 7-oxo-octanal with triethylphosphonoacetate in water, in the presence of potassium carbonate.
- Villieras, J.,Rambaud, M.,Graff, M.
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p. 569 - 580
(2007/10/02)
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