765317-72-4

Basic information

• Product Name: 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide
• Synonyms: 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide;6-BenzofuransulfonaMide, 3-(3,5-dibroMo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylaMino)sulfonyl]phenyl]-;3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide
• CAS NO: 765317-72-4
• Molecular Formula: C26H19Br2N3O7S3
• Molecular Weight: 741.44796
• Mol File: 765317-72-4.mol

Chemical Properties

• Boiling Point: 855°C at 760 mmHg
• Flash Point: 470.9°C
• Appearance: /
• Density: 1.812g/cm³
• Vapor Pressure: 1.11E-30mmHg at 25°C
• Refractive Index: 1.727
• Solubility: Soluble in ethanol and DMSO
• Sensitive: Light Sensitive
• CAS DataBase Reference: 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide(765317-72-4)
• EPA Substance Registry System: 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide(765317-72-4)

Safety Data

• Hazardous Substances Data: 765317-72-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide is used as a PTP1B inhibitor for its ability to selectively inhibit the activity of Protein Tyrosine Phosphatase 1B (PTP1B). PTP1B plays a critical role in cell signaling relevant to diabetes, obesity, and cancer, making 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide a promising candidate for the development of therapeutic agents targeting these conditions.
Used in Research Applications:
3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide is used as a research tool for studying the role of PTP1B in various cellular processes. Its ability to selectively inhibit PTP1B activity allows researchers to investigate the effects of modulating this enzyme on insulin and leptin signaling pathways, as well as its potential role in the development and progression of diabetes, obesity, and cancer.
Used in Drug Discovery and Development:
3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide is used as a lead compound in drug discovery and development efforts. Its unique chemical structure and biological activity make it a valuable starting point for the design and optimization of new therapeutic agents targeting PTP1B and related pathways. Further research and development may lead to the identification of more potent and selective PTP1B inhibitors with improved pharmacological properties for the treatment of diabetes, obesity, and cancer.

InChI:InChI=1/C26H19Br2N3O7S3/c1-2-21-23(24(32)14-11-19(27)25(33)20(28)12-14)18-8-7-17(13-22(18)38-21)41(36,37)30-15-3-5-16(6-4-15)40(34,35)31-26-29-9-10-39-26/h3-13,30,33H,2H2,1H3,(H,29,31)