- Synthesis and biological effects evaluation of benzoconduritols C and D from oxabenzonorbornadiene
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The effective synthesis of benzoconduritols C and D is reported. Oxidation of oxabenzonorbornadiene followed by acetylation with Ac2O/pyridine or AcCl/CH2Cl2 gave the corresponding exo-diacetate compound stereoselectively.
- ?ol Ayvaz, Melek,?ahin, Ertan,Kelebekli, Latif,Y?lmaz, Fatma Zehra
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- 1,2,3,4-TETRAHYDRONAPHTHALENE-1,2,3,4-TETROL COMPOUND AND METHOD FOR PRODUCING THE SAME
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PROBLEM TO BE SOLVED: To provide a completely new polyol compound in the production of a polyester resin, a polyurethane resin, a polycarbonate resin or the like. SOLUTION: There is provided a 1,2,3,4-Tetrahydronaphthalene-1,2,3,4-tetrol compound represented by the formula (1). (X and Y each independently represents an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, an alkylthio group having 1 to 10 carbon atoms, a monoalkylamino group having an alkyl group having 1 to 8 carbon atoms or a dialkylamino group or a halogen atom; X and Y may be bonded to each other to form a saturated or unsaturated ring; Z represents H, a hydroxyl group, an alkyl group having 1 to 5 carbon atoms or a halogen atom.) SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
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Paragraph 0059
(2018/09/08)
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- Chemoenzymatic synthesis of conduritol analogues
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Several conduritol and conduramine analogues have been synthesized from β-substituted naphthalenes via a chemoenzymatic approach, in a high regio- and stereocontrolled way. Several conduritol and conduramine analogues have been synthesized from β-substituted naphthalenes via a chemoenzymatic approach, in a high regio- and stereocontrolled way.
- Orsini, Fulvia,Sello, Guido,Bernasconi, Silvana,Fallacara, Gianfranco
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p. 9253 - 9255
(2007/10/03)
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- Enantiopure arene dioxides: Chemoenzymatic synthesis and application in the production of trans-3,4-dihydrodiols
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Enantiopure syn- and anti-arene dioxides are synthesised from cis-dihydrodiol metabolites; anti-benzene dioxides are reduced to enantiopure trans-3,4-dihydrodiols while synbenzene dioxides racemise thermally via 1,4-dioxocins.
- Boyd,Sharma,O'Dowd,Hempenstall
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p. 2151 - 2152
(2007/10/03)
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- Synthesis and biological evaluation of conduritol and conduramine analogs
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A number of dimeric conduritol and conduramine analogs have been synthesized from naphthalene via a combination of enzymatic and chemical methods to give oxygenated derivatives with high stereo- and regiocontrol in few steps. These compounds have been tested for enzymatic inhibition against common glycosidases.
- Desjardins, Michel,Lallemand, Marie-Christine,Freeman, Stanley,Hudlicky, Tomas,Abboud, Khalil A.
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p. 621 - 628
(2007/10/03)
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- Synthesis of conduritol, conduramine, and validoxylamine analogs from tetrahydronaphthalene-cis-diol
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A range of polycyclic analogs of conduritols and conduramines was prepared concisely, starting from cis-(1R,2S)-1,2-dihydronaphthalenediol. This methodology could be extended to the syntheses of validoxylamine A analogs.
- Lallemand, Marie-Christine,Desjardins, Michel,Freeman, Stanley,Hudlicky, Tomas
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p. 7693 - 7696
(2007/10/03)
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- Chemistry of anti- and syn-1,2:3,4-Naphthalene Dioxides and Their Potential Relevance as Metabolic Intermediates
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The reactivity, site of attack, and stereochemistry of reactions of a variety of nucleophiles with the anti- and syn-1,2:3,4-naphthalene dioxides have been explored.In most cases, substituted tetrahydronaphthalene products arising through attack at the C-1 and C-4 positions in the anti mode were obtained.These isomeric dioxides provide excellent precursors for a number of difficultly accessible 1,4-disubstituted naphthalene derivatives such as 1,4-diphenoxynaphthalene and 1,4-dicyanonaphthalene.Evidence is also presented that anti-naphthalene dioxide constitutes an intermediate metabolite in the rat.
- Tsang, Wing-Sum,Griffin, Gary W.,Horning, M. G.,Stillwell, W. G.
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p. 5339 - 5353
(2007/10/02)
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