766539-53-1Relevant articles and documents
Fused imidazole compounds with indoleamine 2,3-dioxygenase inhibition activity
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Paragraph 0182; 0183; 0184; 0185, (2018/07/10)
The invention relates to fused imidazole compounds, and a preparation method and application thereof. The structure of the compounds is shown in a general formula I, wherein the definitions of each group are as described in the specification. The compounds are capable of selectively inhibiting indoleamine 2,3-dioxygenase (IDO). The compounds provided by the invention can be used as IDO inhibitorsfor the treatment and/or prevention of diseases with the pathological characteristics of IDO mediated tryptophan metabolism pathways, such as cancer, eye diseases, autoimmune diseases, psychological disorders, depression, anxiety and other diseases.
THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE
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Page/Page column 212, (2012/02/02)
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.
NOVEL CARBOXAMIDE DERIVATIVES AS HIV INHIBITORS
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Page/Page column 28-29, (2011/06/19)
The present invention relates to carboxamide derivatives of Formula (I), where B1, B2, X, L, n, R, R1, R2, Z1, Z2, Rx and Ry are as defined in the claims, as compounds and compositions for inhibiting Human Immunodeficiency Virus (HIV) and process for making the compounds.