76676-34-1 Usage
Biological Activity
Potent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 76676-34-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,6,7 and 6 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 76676-34:
(7*7)+(6*6)+(5*6)+(4*7)+(3*6)+(2*3)+(1*4)=171
171 % 10 = 1
So 76676-34-1 is a valid CAS Registry Number.
InChI:InChI=1/C25H38O4.K/c1-4-5-16-14-17-15-18(26)6-10-23(17,2)19-7-11-24(3)20(22(16)19)8-12-25(24,29)13-9-21(27)28;/h15-16,19-20,22,29H,4-14H2,1-3H3,(H,27,28);/q;+1/p-1/t16-,19+,20+,22-,23+,24+,25-;/m1./s1
76676-34-1Relevant articles and documents
Use of antimineralocorticoid compounds against drug withdrawal syndrome
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, (2008/06/13)
PCT No. PCT/FR96/01459 Sec. 371 Date Mar. 16, 1998 Sec. 102(e) Date Mar. 16, 1998 PCT Filed Sep. 19, 1996 PCT Pub. No. WO97/10827 PCT Pub. Date Mar. 27, 1997Compounds having antimineralocorticoid activity suitable for preparing drugs for treating or preventing conditions related to drug dependence or to the spontaneous or induced withdrawal syndrome caused by narcotics or mixtures thereof, and compositions containing same, are disclosed.