New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity
A convenient route to new 3(2H)-furanones is described through hydrogenolysis and subsequent acidic hydrolysis of isoxazoles. The antiproliferative activity of title compounds were evaluated against leukemia-, carcinoma-, neuroblastoma-, and sarcoma-derived human cell lines in comparison to the natural compound geiparvarin. The structure activity relationship indicated that the maximum in vitro antiproliferative activity correlates with the presence of a heterocyclic ring on the ethenyl moiety.
Interest in the total synthesis of natural product antitumor agents which have as a central structural element the 3(2H)-furanone ring system has led to the development of an efficient general synthesis of a variety of simple 3(2H)-furanones.The strategy
Smith, Amos B.,Levenberg, Patricia A.,Jerris, Paula J.,Scarborough, Robert M.,Wovkulich, Peter M.
p. 1501 - 1513
(2007/10/02)
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