- Total synthesis of the antifungal depsipeptide petriellin A
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We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected lin
- Sleebs, Marianne M.,Scanlon, Denis,Karas, John,Maharani, Rani,Hughes, Andrew B.
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p. 6686 - 6693
(2011/10/18)
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- Synthesis and characterization of chiral N-O turns induced by α-aminoxy acids
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Chiral α-aminoxy acids of various side chains were synthesized with high optical purity starting from chiral α-amino acids. The conformations of diamides 13a-e, 15, and 16 were probed by using NMR, FT-IR, and CD spectroscopic methods as well as X-ray crystallography. The right-handed turns with eight-membered-ring intramolecular hydrogen bonds between adjacent residues (called the N-O turns) were found to be preferred for D-aminoxy acid residues, and they were independent of the side chains. The rigid chiral N-O turns should have great potential in molecular design.
- Yang,Li,Ng,Yan,Qu,Wu
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p. 7303 - 7312
(2007/10/03)
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