Novel pyridazinone derivatives as butyrylcholinesterase inhibitors
In the current study, forty-four new [3-(2/3/4-methoxyphenyl)-6-oxopyridazin-1(6H)-yl]methyl carbamate derivatives were synthesized and evaluated for their ability to inhibit electric eel acetylcholinesterase (EeAChE) and equine butyrylcholinesterase (eqB
Dundar, Yasemin,Kuyrukcu, Ozge,Eren, Gokcen,Senol Deniz, F. Sezer,Onkol, Tijen,Orhan, Ilkay Erdogan
(2019/09/30)
COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR
The present disclosure is directed to pyridazinone derivatives of generic formula that modulate, e.g., address underlying defects in cellular processing of CFTR activity.
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Paragraph 0117
(2018/05/24)
PYRIDAZINE DERIVATIVES, COMPOSITIONS AND METHODS FOR MODULATING CFTR
The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity.
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Paragraph 0113
(2018/05/24)
One-pot preparation of 6-substituted 3(2H)-pyridazinones from ketones
A one-pot process for the preparation of 6-phenyl-3(2H)-pyridazinone from acetophenone and glyoxylic acid has been investigated and shown to have wide utility in the preparation of 6- and 5,6-substituted 3(2H)-pyridazinones. Limitations to the process encountered with 2'-hydroxyacetophenone and with basic hetero-aromatic ketones have been overcome, and the processes described offer the rapid and efficient synthesis of many 6-substituted pyridazinones from readily available ketones.
Coates,McKillop
p. 334 - 342
(2007/10/02)
Synthesis and Anxiolytic Activity of 6-(Substituted-phenyl)-1,2,4-triazolopyridazines
The synthesis of a series of 6-(substituted-phenyl)-1,2,4-triazolopyridazines (VIII) is reported.Some of these derivatives show activity in tests predictive of anxiolytic activity (a) protection against pentylenetetrazole-induced convulsions; (b)
Albright, J. D.,Moran, D. B.,Wright, W. B.,Collins, J. B.,Beer, B.,et al.
p. 592 - 600
(2007/10/02)
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