cas 77-01-0, Fenpipramide | Articles data ｜lookchem

Welcome to LookChem.com Sign In|Join Free

Article Database

Home > CAS Article list >
77-01-0

Articles about 77-01-0Total 1 be found

Article title
Article abstract
Author
Journal number and time
Download

Overcoming chloroquine resistance in malaria: Design, synthesis and structure-activity relationships of novel chemoreversal agents
Malaria remains a significant infectious disease with even artemisinin-based therapies now facing resistance in the field. Development of new therapies is urgently needed, either by finding new compounds with unique modes of action, or by reversing resistance towards known drugs with 'chemosensitizers' or 'chemoreversal' agents (CRA). Concerning the latter, we have focused on the resistance mechanisms developed against chloroquine (CQ). We have synthesized a series of compounds related to previously identified CRAs, and found promising novel compounds. These compounds show encouraging results in a coumarin labeled chloroquine uptake assay, exhibiting a dose response in resensitising parasites to the antimalarial effects of chloroquine. Selected compounds show consistent potency across a panel of chloroquine and artemisinin sensitive and resistant parasites, and a wide therapeutic window. This data supports further study of CRAs in the treatment of malaria and, ultimately, their use in chloroquine-based combination therapies.
Boudhar, Aicha,Ng, Xiao Wei,Loh, Chiew Yee,Chia, Wan Ni,Tan, Zhi Ming,Nosten, Francois,Dymock, Brian W.,Tan, Kevin S.W.
p. 231 - 249
(2016/05/24)

More Articles about upstream products of 77-01-0

More Articles about downstream products of 77-01-0

Chemical Properties

Melting Point: 186-187 °C
Boiling Point: 534.5°C at 760 mmHg
Flash Point:277°C
Density: 1.098g/cm³
Vapor Pressure: 1.68E-11mmHg at 25°C
PKA: 15.80±0.50(Predicted)
PSA: 46.33000
LogP: 3.97220

Show more

Global suppliers and manufacturers of 77-01-0total 13 suppliers on LookChem

Company Name
Business Type
Min Order
FOB Price
Main Products
Contact

Dayang Chem (Hangzhou) Co.,Ltd.
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:USD $ 3.0-3.0 / Kilogram
Main Products:994
Country:

Shanghai Upbio Tech Co.,Ltd
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:No Data
Main Products:30
Country:

Henan Wentao Chemical Product Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:44
Country:

Hangzhou Keyingchem Co.,Ltd
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:102
Country:

Bluecrystal chem-union
Business Type:Trading Company
Min Order:1 Metric Ton
FOB Price:USD $ 1.0-1.0 / Metric Ton
Main Products:7
Country:

Antimex Chemical Limied
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:163
Country:

BOC Sciences
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:41
Country:

Hangzhou Fandachem Co.,Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:52
Country:

Henan Kanbei Chemical Co.,LTD
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:61
Country:

Hubei Jiutian Bio-medical Technology Co., Ltd
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:23
Country:

Shanghai Chinqesen Biotechnology Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:79
Country:

ZHEJIANG JIUZHOU CHEM CO.,LTD
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:27
Country:

LEAP CHEM Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:88
Country:

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 77-01-0

About us - Payment - Contact us - Links - Help Center - Disclaimer
SiteMap | Manufacturers | VIP Product | Suppliers | CAS | New CAS | Cas Database | Article Data | Chemical Catalog | Product Name

©2008 LookChem.com,License:ICP NO.:Zhejiang16009103 complaints:service@lookchem.com
[Hangzhou]86-571-87562588,87562561,87562573 Our Legal adviser: Lawyer