Potent inhibitors of the hepatitis C virus NS3 protease: Design and synthesis of macrocyclic substrate-based β-strand mimics
The virally encoded NS3 protease is essential to the life cycle of the hepatitis C virus (HCV), an important human pathogen causing chronic hepatitis, cirrhosis of the liver, and hepatocellular carcinoma. The design and synthesis of 15-membered ring β-strand mimics which are capable of inhibiting the interactions between the HCV NS3 protease enzyme and its polyprotein substrate will be described. The binding interactions between a macrocyclic ligand and the enzyme were explored by NMR and molecular dynamics, and a model of the ligand/enzyme complex was developed.
Get Best Price for770742-57-9(2S,4R)-2-((R)-2-Allylsulfanyl-1-methoxycarbonyl-ethylcarbamoyl)-4-(7-methoxy-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester