- IMIDAZOPYRIMIDINES AS EED INHIBITORS AND THE USE THEREOF
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The present disclosure provides compounds represented by Formula (I) wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula (I) are FED inhibitors. FED inhibitors are useful for the treatment of cancer and other diseases.
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Paragraph 0453
(2021/02/12)
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- Concise copper-catalyzed synthesis of tricyclic biaryl ether-linked aza-heterocyclic ring systems
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A new method for the synthesis of tricyclic biaryl ether-linked ring systems incorporating seven-, eight-, and nine-membered ring amines is presented. In the presence of catalytic quantities of copper(I), readily accessible acyclic precursors undergo an intramolecular carbon-oxygen bond-forming reaction facilitated by a templating chelating nitrogen atom. The methodology displays a broad substrate scope, is practical, and generates rare and biologically interesting tricyclic heteroaromatic products that are difficult to access by other means.
- Mestichelli, Paola,Scott, Matthew J.,Galloway, Warren R. J. D.,Selwyn, Jamie,Parker, Jeremy S.,Spring, David R.
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supporting information
p. 5448 - 5451
(2013/11/19)
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- New CRTh2 antagonists.
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The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.
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Paragraph 0171
(2013/03/26)
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- NEW CRTh2 ANTAGONISTS
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The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.
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Page/Page column 60-61
(2013/03/26)
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- Formation of optically pure cyclic amines by intramolecular conjugate displacement
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Intramolecular conjugate displacement (ICD) has been applied to the Morita-Baylis-Hillman adducts formed from (5S)-5-(l-menthyloxy)-2(5H)-furanone and aldehydes that carry a protected β- or γ-amino group. DIBAL-H reduction of the resulting ICD products releases optically pure six- or seven-membered cyclic amines having a stereogenic center α to nitrogen.
- Cheng, Ping,Clive, Derrick L. J.
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scheme or table
p. 3348 - 3364
(2012/05/20)
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