Studies on Pyrimidine Derivatives. XX. Synthetic Utility of Hydroxymethylpyrimidines and Related Compounds
The conversion of a hydroxymethyl group at the 2- or 4-position of simple pyrimidines to a chloromethyl, cyanomethyl, ethoxycarbonylmethyl, or formyl group is described.Various pyrimidines having an olefinic side chain were also synthesized via Witting reagents derived from chloromethylpyrimidines.Keywords - hydroxymethylation; chloromethylpyrimidine; cyanomethylpyrimidine; pyrimidinecarbaldehyde; Witting reaction