β-Lactam antibiotics, a process for their prepaeration and their use in pharmaceutical compositions
The present invention provides the antibacterial agents of the formula (II): STR1 wherein R1 is a group such that CO2 R1 is a carboxylic acid group or a salt thereof or is a group of the formula CO2 R11 wherein R11 is a group such that CO2 R11 is an ester group, R2 is a hydrogen atom or a lower alkyl group; R3 is a hydrogen atom or a lower alkyl group; and R4 is a NH. COn R6 group where R6 is a lower alkyl group, a phenyl group or a phenyl group substituted by one or two halogen atoms, lower alkyl or lower alkoxyl groups; and n is 1 or 2. A process for their preparation and their use in pharmaceutical compositions is also described.
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(2008/06/13)
Cephalosporins
Cephalosporin analogues of the formula (I): SPC1 and their salts and in-vivo hydrolysable esters (wherein R is an acyl group as found in known antibacterially active penicillins and cephalosporins and R1 is a hydrogen atom or a carboxylic acid group) are useful antibacterial agents.
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(2008/06/13)
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