Negative inotropic activity of para-substituted diethyl benzylphosphonates related to fostedil
Several para-substituted diethyl benzylphosphonates related to the calcium antagonist diethyl 4-(2-benzothiazolyl)benzylphosphonate (fostedil) have been studied.They produce a dose-dependent negative inotropic effect on left atrial muscle isolated from guinea pig heart.Some of the compounds are equipotent or slightly more potent than fostedil and diltiazem taken as reference drugs.Structure-activity relationships are discussed.Keywords: calcium antagonists / p-substituted diethyl benzylphosphonates / cardiodepressant activity
Bellucci, Christina,Gualtieri, Fulvio,Chiarini, Alberto
p. 473 - 478
(2007/10/02)
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