773134-78-4

Basic information

• Product Name: Ethyl 4-(difluoroMethoxy)benzoate
• Synonyms: Ethyl 4-(difluoroMethoxy)benzoate
• CAS NO: 773134-78-4
• Molecular Formula: C₁₀H₁₀F₂O₃
• Molecular Weight: 216.1814064
• Mol File: 773134-78-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 4-(difluoroMethoxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-(difluoroMethoxy)benzoate(773134-78-4)
• EPA Substance Registry System: Ethyl 4-(difluoroMethoxy)benzoate(773134-78-4)

Safety Data

• Hazardous Substances Data: 773134-78-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Ethyl 4-(difluoroMethoxy)benzoate is employed as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Flavor and Fragrance Industry:
Leveraging its strong fruity odor, Ethyl 4-(difluoroMethoxy)benzoate is used as a flavor and fragrance ingredient in the food and beverage industry, enhancing the sensory experience of products.
Used in Solvent Applications:
Ethyl 4-(difluoroMethoxy)benzoate also serves as a solvent in various applications, including the production of paints and coatings, where its properties aid in the manufacturing process and final product performance.
Used in Fine Chemicals Industry:
Ethyl 4-(difluoroMethoxy)benzoate is utilized in the synthesis of fine chemicals, which are high-purity chemicals used in various specialized applications, such as research, diagnostics, and high-value industrial processes.

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 1885-46-7 trifluoromethanesulfonic acid difluoromethyl ether 
• 64-17-5 ethanol 
• 4837-20-1 4-(difluoromethoxy)benzoic acid 
• 1895-39-2 sodium chlorodifluoroacetate 

Relevant articles and documents

Difluoromethylation of Phenols and Thiophenols with the S-(Difluo-romethyl)sulfonium Salt: Reaction, Scope, and Mechanistic Study

A facile and practical approach for the difluoromethylation of phenols and thiophenols was described. Making use of the recently developed bench-stable S-(difluoromethyl)sulfonium salt as the difluorocarbene precursor, a wide variety of diversely functionalized phenols and thiophenols were readily converted to their corresponding aryl difluoromethyl ethers in good to excellent yields in the presence of lithium hydroxide. Chemoselectivity of various O,S-nucleophiles toward difluorocarbene was systematically studied, suggesting the reactivity order ArS- > RS-, ArO- > ROH > RO-, ArSH, ArOH, RSH.

SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF

The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES

The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone- depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

SYNTHESIS OF PYRAZOLES

The present invention provides methods of making HCl salts, and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other