- Can Coordination-Driven Supramolecular Self-Assembly Reactions Be Conducted from Fully Aliphatic Linkers?
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The reaction between a preassembled CuI bimetallic molecular clip with a short intermetallic distance and a series of fully aliphatic cyano-capped ditopic linkers with increasing lengths was investigated. It is shown that, depending on the leng
- Elsayed Moussa, Mehdi,Evariste, Sloane,Kr?mer, Barbara,Réau, Régis,Scheer, Manfred,Lescop, Christophe
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Read Online
- Diamines for Polymer Materials via Direct Amination of Lipid- and Lignocellulose-based Alcohols with NH3
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Via an all-catalytic route, long-chain diamines were prepared by the catalytic direct amination of long-chain diols, derived from plant oils. High conversion was achieved with good selectivity, with the amount of nitrile impurities formed suppressed to a low level. From the lignocellulose-based 5-hydroxymethylfurfural (5-HMF), or from bis(hydroxymethyl)furan, 2,5-bis(aminomethyl)furan (BAMF) was generated. 5-HMF was converted in a one-pot, one-step direct amination and reductive amination using ammonia. In both cases, the reaction proceeded very efficiently. In the combined amination and reductive amination, the H2 concentration is a rate-limiting factor. Reducing the partial pressure of H2 also shortened the reaction time required significantly. Polycondensation of the long-chain diamines with long-chain diacids led to higher molecular weight polyamides, illustrating the quality of the diamines obtained by this synthetic approach as monomers.
- Pingen, Dennis,Schwaderer, Judith B.,Walter, Justus,Wen, Jiaqi,Murray, George,Vogt, Dieter,Mecking, Stefan
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p. 3027 - 3033
(2018/05/29)
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- Iridium-catalyzed α-alkylation of acetonitrile with primary and secondary alcohols
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Acetonitrile is successfully alkylated with primary and secondary alcohols in the presence of t-BuOK using [Ir(OH)- (cod)]2 as a catalyst. This method provides a very clean and atom-economical convenient direct route to substituted nitriles, which are very important raw materials in organic and industrial chemistry.
- Sawaguchi, Takuya,Obora, Yasushi
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supporting information; experimental part
p. 1055 - 1057
(2011/12/05)
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- Potent antimalarial activity of 2-aminopyridinium salts, amidines, and guanidines
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We describe the design, synthesis, and antimalarial activity of 60 bis-tertiary amine, bis-2(1H)-imino-heterocycle, bis-amidine, and bis-guanidine series. Bis-tertiary amines with a linker from 12 to 16 methylene groups were active against the in vitro growth of Plasmodium falciparum within the 10 -6-10-7 M concentration range. IC50 decreased by 2 orders of magnitude for bis-2-aminopyridinium salts, bis-amidines, and bis-guanidines (27 compounds with IC50 a over 12.5. Maximal activity occurs for bis-2-aminopyridinium, two C-duplicated bis-amidines, and three bis-guanidines, with IC50 values lower than 1 nM. In comparison to similar quaternary ammonium salts, amidinium compounds have distinct structural requirements for antimalarial activity and likely additional binding opportunities on account of their hydrogen-bond-forming properties.
- Calas, Michèle,Ouattara, Mahama,Piquet, Gilles,Ziora, Zyta,Bordat,Ancelin, Marie L.,Escale, Roger,Vial, Henri
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p. 6307 - 6315
(2008/09/16)
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- Compounds with antiparasitic activity and medicines containing same
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The invention relates to compounds having an anti-parasitic, in particular antimalarial activity, characterized in that they correspond to general formula (I) Applications in particular as compounds with anti-parasitic activity.
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Page/Page column 6
(2008/06/13)
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- SYNTHESIS OF PENTADECANEDIOIC ACID FROM CYCLODECANONE OR DODECANEDIOIC ACID
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Methods were developed for the production of pentadecanedioic acid from cyclododecanone or dodecanedioic acid.
- Zakharkin, L. I.,Guseva, V. V.
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p. 281 - 284
(2007/10/02)
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