- Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease
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Avarol is a marine sesquiterpenoid hydroquinone, previously isolated from the marine sponge Dysidea avara Schmidt (Dictyoceratida), with antiinflammatory, antitumor, antioxidant, antiplatelet, anti-HIV, and antipsoriatic effects. Recent findings indicate
- Tommonaro, Giuseppina,García-Font, Nuria,Vitale, Rosa Maria,Pejin, Boris,Iodice, Carmine,Ca?adas, Sixta,Marco-Contelles, José,Oset-Gasque, María Jesús
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p. 326 - 338
(2016/07/07)
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- Total synthesis of polyprenylhydroquinols and benzoquinones
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The total synthesis of polyprenylhydroquinols and benzoquinones is described.First, two appropriate aromatic allyl carbonates (moieties with one and two prenyls) and two activated bifunctional terpenyl derivatives (moieties with two and three prenyls) were synthesized.These molecules were then reacted together using a highly regio- and stereoselective coupling with Pd(PPh3)4 as a catalyst.The synthesis was achieved by functional group elimination and formation of quinonic and hydroquinonic moieties. - Keywords: polyprenylbenzoquinol; polyprenylhydroquinone; allylcarbonate; ?-allyl palladium complex
- Bouzbouz, Samir,Kirschleger, Bernard,Villieras, Jean
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- DEPROTECTION OF TETRAHYDROPYRANYL ETHERS WITH A MEXICAN BENTONITE. SYNTHESIS OF FARNESYLHYDROQUINONE
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A new method for deprotecting tetrahydropyranyl ethers has been established by using a bentonitic earth.The reaction proceeds selectively under mild conditions in good yields.The heterogenous reaction enables easy separation of the parent hydroxyl functionality by simple filtration.The synthesis of farnesylhydroquinone as a synthetic application of the method is also reported.
- Cruz-Almanza, R.,Perez-Flores, F. J.,Avila, M.
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p. 1125 - 1131
(2007/10/02)
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- TERPENOIDS ISOLATED FROM WIGANDIA KUNTHII
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- Key Word Index: Wigandia kunthii; Hydrophyllaceae; farnesylhydroquinone; benzocyclodecadiene, wigandol.
- Gomez, F.,Quijano, L.,Calderon, J. S.,Rios, T.
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p. 2202 - 2203
(2007/10/02)
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