- New diterpenoids from the roots of Euphorbia ebracteolata Hayata
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Three new diterpenoids, ingenol-5,20-O,O-isopropylidene-3-palmitate (1), ingenol-5,20-O,O-isopropylidene-3-myristinate (2) and 3,19-dihydroxy-1(10),15- rosadien-2-one (3), were isolated from the roots of Euphorbia ebracteolata Hayata. Their structures wer
- Deng, Bin,Mu, Shu-Zhen,Zhang, Jian-Xin,Hao, Xiao-Jiang
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experimental part
p. 1503 - 1509
(2010/11/02)
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- On the Chemistry of Ingenol, I. Ingenol and Some of its Derivatives
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The tetracyclic polyfunctional diterpene ingenol (1) is the prototype of many diterpenoid parent alcohols of the ingenane type.Esters of these parent alcohols occur-partly together with esters of polyfunctional diterpene parent alcohols of the tigliane and daphnane type - as irritant, cocarcinogenic and antineoplastic principles in spesies of the family Euphorbiaceae (Spurge).Preparation of 1 from latex of Euphorbia ingens E.May as well as of some functional derivatives of 1 are described. - Key words: Cocarcinogens, Diterpene Esters, Euphorbiaceae, Tumor Promoters
- Opferkuch, H. J.,Adolf, W.,Sorg, B.,Kusumoto, S.,Hecker, E.
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p. 878 - 887
(2007/10/02)
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