One-pot synthesis of trisubstituted ureas from achloroaldoxime O-methanesulfonates and secondary amines
Trisubstituted ureas can be synthesized in a one-pot fashion from bench-stable a-chloroaldoxime Omethanesulfonates and secondary amines under mild reaction conditions. Two practical protocols have been developed to achieve various urea syntheses from both secondary aromatic amines and aliphatic amines.