7774-65-4

Basic information

• Product Name: TERPINYL ISOBUTYRATE
• Synonyms: 2-methyl-propanoicaci1-methyl-1-(4-methyl-3-cyclohexen-1-yl)ethylester;2-methylpropanoicacid1-methyl-1-(4-methyl-3-cyclohexen-1-yl)ethylester;Propanoicacid,2-methyl-,1-methyl-1-(4-methyl-3-cyclohexen-1-yl)ethylester;P-MENTH-1-EN-8-YL-ISOBUTYRATE;PARA METHYL-1-EN-8-YL ISOBUTYRATE;TERPINYL ISOBUTYRATE;TERPINYL ISOBUTYRATE ALPHA;FEMA 3050
• CAS NO: 7774-65-4
• Molecular Formula: C₁₄H₂₄O₂
• Molecular Weight: 224.34
• EINECS: 231-878-5
• Mol File: 7774-65-4.mol

Chemical Properties

• Boiling Point: 242 °C(lit.)
• Flash Point: >230 °F
• Appearance: clear, colourless liquid
• Density: 0.943 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00607mmHg at 25°C
• Refractive Index: n20/D 1.461(lit.)
• CAS DataBase Reference: TERPINYL ISOBUTYRATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERPINYL ISOBUTYRATE(7774-65-4)
• EPA Substance Registry System: TERPINYL ISOBUTYRATE(7774-65-4)

Safety Data

• WGK Germany: 2
• RTECS: UA2470450
• Hazardous Substances Data: 7774-65-4(Hazardous Substances Data)

Usage

Uses

Used in Flavor and Fragrance Industry:
Terpinyl isobutyrate is used as a flavoring agent for its fruity and floral taste, adding a pleasant aroma to food products and beverages.
Terpinyl isobutyrate is also used as a fragrance component in perfumes, soaps, and other personal care products, providing a refreshing and natural scent.
Used in Aromatherapy:
Due to its pleasant and soothing scent, Terpinyl isobutyrate is used in aromatherapy to promote relaxation and stress relief.
Used in Cosmetics:
Terpinyl isobutyrate is used in cosmetics as a fragrance ingredient, enhancing the sensory experience of skincare and beauty products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Terpinyl isobutyrate is used as a flavoring agent in medications to improve their taste and make them more palatable for patients.

Preparation

By esterification of terpineol with isobutyric acid

InChI:InChI=1/C14H24O2/c1-10(2)13(15)16-14(4,5)12-8-6-11(3)7-9-12/h6,10,12H,7-9H2,1-5H3

Upstream product

• 98-55-5 terpineol 
• 97-72-3 2-Methylpropionic anhydride 

Relevant articles and documents

Discovery of a novel series of α-terpineol derivatives as promising anti-asthmatic agents: Their design, synthesis, and biological evaluation

A series of novel α-terpineol derivatives were designed and synthesized through structural derivatization of the tertiary hydroxyl moiety or reduction of the double bond. Of the resulting compounds, eight compounds enhanced relaxation of airway smooth muscle (ASM) compared to the α-terpineol precursor, and four compounds (4a, 4d, 4e, and 4i)were superior or comparable to aminophylline at a concentration of 0.75 mmol/L. Assays for 3′-5′-Cyclic adenosine monophpsphate (cAMP) activation revealed that some representative α-terpineol derivatives in this series were capable of upregulating the level of cAMP in ASM cells. Further in vivo investigation using the asthmatic rat model, illustrated that treatment with the compounds 4a and 4e resulted in significantly lowered lung resistance (RL) and enhanced dynamic lung compliance (Cldyn), two important parameters for lung fuction. Moreover, treatment with 4e downregulated the levels of both IL-4 and IL-17. Due to its several favorable physiological functions, including ASM relaxation activity, cAMP activation capability, and in vivo anti-asthmatic efficacy, 4e is a promising remedy for bronchial asthma, meriting extensive development.

Α- [...] enol derivative and its preparation method and application

The invention discloses alpha-terpineol derivatives, the structure of which is shown as the formula (II), wherein R or H is C1-C5 alkyl. The alpha-terpineol derivatives can be obtained by performing esterification reaction on a raw material alpha-terpineol with acid or acid anhydride at the temperature of 18-30DEG C under the action of 4-methylbenzenesulfonyl chloride. The invention further discloses applications of the alpha-terpineol derivatives in preparing antiasthmatic drugs, carboxylic ester prodrug formed by introducing carboxylic ester on the hydroxyl of the alpha-terpineol derivatives can be slowly hydrolyzed in a human body to release parent drug and further prolong the curative effect and the acting time, in addition the bioavailability can be improved, and the antiasthma activity can be further enhanced.