- Rhodium-containing hypercross-linked polystyrene as a heterogeneous catalyst for the hydroformylation of olefins in supercritical carbon dioxide
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A simple procedure for the incorporation of rhodium nanoparticles into a hypercross-linked polystyrene matrix is developed. The prepared heterogeneous catalyst shows high activity in the hydroformylation of olefins in supercritical carbon dioxide, and can be recycled six times without any noticeable decrease in productivity.
- Lyubimov, Sergey E.,Rastorguev, Eugenie A.,Lubentsova, Kseniya I.,Korlyukov, Alexander A.,Davankov, Vadim A.
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p. 1116 - 1119
(2013/04/10)
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- New acyclic (π-Allyl)-closo-rhodacarboranes with an agostic CH 3...Rh bonding interaction that operate as unmodified rhodium-based catalysts for alkene hydroformylation
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A series of new agostic (CH3...Rh) (π-allyl)-closo- rhodacarboranes (π-allyl = 1,1-dimethylallyl, 1,2-dimethylallyl, 1,1,2-trimethylallyl, 1,2,3-trimethylallyl), stable in the solid state, have been synthesized via one-pot reactions between the K+ salts of the [7-R-8-R′-7,8-nido-C2B9H10]- monoanions (1a, R = R′ = Me; 1b, R,R′ = μ-(o-xylylene); 1c, R,R′ = μ-(CH2)3) and the di-μ-chloro cyclooctene rhodium dimer [(η2-C8H14) 4Rh2(μ-Cl)2] (2) in the presence of a 3-fold excess of the conjugated 1,3-dienes 2-methylbuta-1,3-diene (isoprene, 3), 2,3-dimethylbuta-1,3-diene (4), and 3-methylpenta-1,3-diene (5). The agostic structures of [3-{(1-3-η3)-1,1-dimethylallyl}-1,2-(CH 3)2-3,1,2-closo-RhC2B9H 9] (7a) and [3-{(1-3-η3)-1,1,2-trimethylallyl}-1,2- (CH3)2-3,1,2-closo-RhC2B9H 9] (8a) have been unambiguously confirmed by single-crystal X-ray diffraction studies. Two of these π-allyl complexes prepared were evaluated for their efficacy in hydroformylation of the model alkenes under syngas (CO/H2) using supercritical carbon dioxide (scCO2) as the solvent, and both display excellent conversion and high regioselectivity in the formation of aldehyde products.
- Galkin, Konstantin I.,Lubimov, Sergey E.,Godovikov, Ivan A.,Dolgushin, Fedor M.,Smolyakov, Alexander F.,Sergeeva, Elena A.,Davankov, Vadim A.,Chizhevsky, Igor T.
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p. 6080 - 6084
(2012/10/30)
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- PYRAZOLO-TETRAHYDROPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
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The invention relates to novel pyrazolo-tetrahydropyridines compounds and their use as orexin receptor antagonists.
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Page/Page column 23
(2011/02/18)
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- PYRAZOLO-TETRAHYDRO PYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
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The invention relates to novel pyrazolo-tetrahydropyridines compounds and their use as orexin receptor antagonists.
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Page/Page column 11; 18
(2009/04/24)
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- 1,4-Dihydropyridine derivatives
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A 1,4-dihydropyridine derivative having the formula (I): wherein, R1represents a substituted or unsubstituted phenyl or pyridyl group, R2represents a C1to C5lower alkyl group, R3represents a substituted or unsubstituted C1to C8alkyl, alkenyl, alkynyl or substituted or unsubstituted C3to C7cycloalkyl or cycloalkenyl group, R4represents —A—R5, wherein A represents a C3to C5alkynylene group having one triple bond, and R5represents a substituted or unsubstituted pyridyl, quinolyl, isoquinolyl or pyrimidyl group and a drug for overcoming resistance to an anti-cancer drug or a drug increasing the effect of an anti-cancer drug containing as an effective ingredient the derivative or its pharmacologically acceptable salt or hydrate.
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- Synthesis of cis- and trans-Isomers of Ethyl 5-(4'-Isopropylphenyl)-2-methyl-2-pentenoate (Ethyl Nidorellaurinate)
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Conjugate addition of p-isopropylphenylmagnesium bromide to ethyl acrylate yields ethyl 3-(4'-isopropylphenyl)propionate (II) which on LAH reduction followed by subsequent oxidation affords IV.IV on modified Wittig reaction with ethyl α-diethyl phosphonopropionate furnishes the cis-(IA)- and trans-(IB)-isomers of the title compound.
- Vig, O. P.,Bari, S. S.,Singh, K.,Dua, D. M.
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p. 619 - 620
(2007/10/02)
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- SYNTHESIS OF dl-METHYL NIDORELLAURINATE
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A four-step synthesis of the sesquiterpene methyl nidorellaurinate from perillaldehyde is described
- Ho, Tse-Lok
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p. 605 - 608
(2007/10/02)
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