The selective synthesis of fluorophenol derivatives starting from tert-butylphenol derivatives and fluorinating reagents is described. tert-Butylfluorophenol derivatives were treated with an aluminum chloride catalyst in toluene to afford the fluorophenol derivatives.
Takemoto, Ichiki,Yamasaki, Kaori
p. 594 - 595
(2007/10/02)
DIRECT FLUORINATION OF PHENOL AND CRESOLS
A study has been made of the reaction of phenol with elemental fluorine using a variety of solvents and reaction temperatures.Yields of o- and p-fluorophenol were obtained as high as 85percent.The isomer ratio changed drastically between phenol conversions of 10percent and 56percent.The o-isomer changed to unidentified polymeric substances at higher conversion, but it might also be assumed that interconversion of some isomers is occuring.The three cresols have also been succesfully fluorinated with elemental fluorine. p-Cresol gave some expected 2-fluoroderivative but also formed a fluorocyclohexadienyl ketone.
Misaki, Susumu
p. 159 - 172
(2007/10/02)
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