Practical synthesis of 1-aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6-exo amide-epoxide cyclization
(Chemical Equation Presented) Chiral 1-aryl-6-(hydroxymethyl)-2- ketopiperazines can be prepared via an operationally simple, 6-exo epoxide ring-opening cyclization to form the ketopiperazine C6-N1 bond in high yields and with excellent enantiomeric purity.
Powell, Noel A.,Ciske, Fred L.,Clay, Emma C.,Cody, Wayne L.,Downing, Dennis M.,Blazecka, Peter G.,Holsworth, Daniel D.,Edmunds, Jeremy J.
p. 4069 - 4072
(2007/10/03)
PIPERAZINE DERIVATIVE RENIN INHIBITORS
Disclosed are piperazine derivatives, their manufacture and use as inhibitors of renin. Formula (I):
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Page 58; 61
(2010/02/09)
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