Synthesis and evaluation of 2-anilino-3-phenylsulfonyl-6-methylpyridines as corticotropin-releasing factor1 receptor ligands
A novel series of 2-anilino-3-phenylsulfonyl-6-methylpyridines was synthesized and evaluated as corticotropin-releasing factor receptor ligands. Structure-activity relationship studies focused primarily on optimization of the 3-phenylsulfonyl group. Compo
Hartz, Richard A.,Arvanitis, Argyrios G.,Arnold, Charles,Rescinito, Joseph P.,Hung, Kimberly L.,Zhang, Ge,Wong, Harvey,Langley, David R.,Gilligan, Paul J.,Trainor, George L.
p. 934 - 937
(2007/10/03)
Pyridinyl derivatives for the treatment of depression
The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) useful for the treatment of depression, anxiety, aff
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Page column 14
(2010/02/08)
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