- Formal [5+1] annulation reactions of dielectrophilic peroxides: Facile access to functionalized dihydropyrans
-
A general [5+1] annulation reaction, which utilized 4-bromo- or 4-mesyloxy-but-2-enyl peroxides as unique five-atom bielectrophilic synthons to participate in the C-C and the subsequent umpolung C-O bond-forming reactions with C1 nucleophiles, has been developed for the facile synthesis of 2,2-disubstituted dihydropyrans in high yields under mild basic conditions. The dihydropyrans, which are readily prepared on a gram scale by this new method, can be flexibly transformed into the biologically important tetrahydropyrans and pyranones in 1-2 steps.
- Zhong, Chen,Yin, Qi,Zhao, Yukun,Li, Qinfeng,Hu, Lin
-
supporting information
p. 13189 - 13192
(2020/11/09)
-
- Synthesis of 2,3-diaryl-1,4-diazolyl-2,3-epoxybutanes
-
2,3-Diaryl-1,4-diazolyl-2,3-epoxybutanes have been prepared from dimethylstilbenes.An efficient although neglected synthesis of the required olefins has been recovered from the literature.The target compounds show moderate antifungal activity.
- Moreno-Manas, M.,Teixido, M.
-
p. 1439 - 1441
(2007/10/02)
-