77862-92-1

Basic information

• Product Name: Falipamil
• Synonyms: 2-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-2,3-dihydro-5,6-dimethoxy-1H-isoindol-1-one;2-[3-[2-(3,4-Dimethoxyphenyl)ethyl(methyl)amino]propyl]-2,3-dihydro-5,6-dimethoxy-1H-isoindol-1-one;AQ-A-39;Falipamil
• CAS NO: 77862-92-1
• Molecular Formula: C₂₄H₃₂N₂O₅
• Molecular Weight: 428.52
• Mol File: 77862-92-1.mol

Chemical Properties

• Boiling Point: 597.1°C at 760 mmHg
• Flash Point: 314.9°C
• Appearance: /
• Density: 1.146g/cm³
• Vapor Pressure: 3.2E-14mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Falipamil(CAS DataBase Reference)
• NIST Chemistry Reference: Falipamil(77862-92-1)
• EPA Substance Registry System: Falipamil(77862-92-1)

Safety Data

• Hazardous Substances Data: 77862-92-1(Hazardous Substances Data)

Usage

Uses

Falipamil is a specific bradycardic agent and a calcium channel blocker.

InChI:InChI=1/C24H32N2O5/c1-25(12-9-17-7-8-20(28-2)21(13-17)29-3)10-6-11-26-16-18-14-22(30-4)23(31-5)15-19(18)24(26)27/h7-8,13-15H,6,9-12,16H2,1-5H3

Upstream product

• 3490-06-0 N-methylhomoveratrylamine 
• 1163250-40-5 2-(3-chloropropyl)-5,6-dimethoxyisoindolin-1-one 
• 5763-61-1 3,4-dimethoxybenzylamine 
• 55982-99-5 1-[N-methyl-N-(2(3,4-dimethoxy-phenyl)-ethyl)-amino]-3-aminopropane 
• 4821-94-7 4,5-dimethoxyphthalic anhydride 
• 60987-15-7 2-{3-[(3,4-dimethoxy-phenethyl)-methyl-amino]-propyl}-5,6-dimethoxy-isoindole-1,3-dione 

Relevant articles and documents

Palladium-Catalyzed Direct C-H Carbonylation of Free Primary Benzylamines: A Synthesis of Benzolactams

A protocol for palladium-catalyzed C-H carbonylation of readily available free primary benzylamines using NH2 as the chelating group under an atmospheric pressure of CO has been achieved, providing a general, atom- and step-economic approach to

Complementary synthetic approaches to constitutionally diverse N-aminoalkylated isoindolinones: Application to the synthesis of falipamil and 5-HT1A receptor ligand analogues

Different synthetic approaches for the elaboration of poly and diversely substituted isoindolinones tailed with constitutionally diverse aminoalkylated chains have been developed. The key step is based upon the preliminary assembly of the isoindolinone te

Specific bradycardic agents. 1. Chemistry, pharmacology, and structure-activity relationships of substituted benzazepinones, a new class of compounds exerting antiischemic properties

Structural modification of the calcium-antagonist verapamil (1) by replacement of the lipophilic α-isopropylacetonitrile moiety by various heterocyclic ring systems has led to a new class of cardiovascular compounds which are characterized by a specific bradycardic activity. These agents reduce heart rate without binding to classical calcium channels or β-adrenoceptors, interacting instead specifically with structures at the sino atrial node. Therefore they have also been termed sinus node inhibition. The prototype falipamil (2) has been submitted to furthr optimization mainly hy manipulation of the phthalimidine moiety. This has resultd in a secod generation of specific bradycardic agents with increased potency and selectively and prolonged duration of action represented by the benzazepinone-derivative UL-FS 49 (4). Structure-activity relationships within this novel class of compounds have revealed a marked dependence of activity on the substitution pattern of the aromatic rings, the nature of the central nitrogen atom, and the length of the connecting alkyl chains. The crucial role of the benzazepione ring for bradycardic activity can be best explained by its special impact on the overall molecular conformation.