- Process for the Monotopic Preparation of Intermediate Organo-Iodinated Compounds for the Synthesis of Ioversol
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The invention relates to a process for the preparation of organo-iodinated compounds as well as the preparation intermediates thereof. More specifically, the invention relates to a process for the preparation of organo-iodinated compounds useful as preparation intermediates in the synthesis of the contrast product ioversol.
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- New Methods for Preparing an Intermediate of Contrast Medium and Methods for Preparing Contrast Medium
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A manufacturing method of the present invention reduces treatment processes when manufacturing a contrast medium or an intermediate thereof, and thus generates less waste solvent, thereby being eco-friendly and capable of significantly reducing a manufacturing cost. Therefore, the manufacturing method of the present invention is economical and suitable for mass production since the production cost of the contrast medium can be greatly reduced.
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Paragraph 0108-0113; 0114; 0119-0121; 0122; 0127-0129
(2020/10/07)
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- New Methods for Preparing an Intermediate of Contrast Medium and Methods for Preparing Contrast Medium
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The present invention relates to a method for preparing an intermediate of contrast agent or contrast agent. Also, the manufacturing cost can be significantly reduced. , The manufacturing method of the present invention can greatly reduce the production cost of contrast agents and is suitable for mass production. (by machine translation)
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Paragraph 0103; 0108-0114; 0119-0122; 0126-0129; 0130-0132
(2020/10/14)
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- METHOD FOR PREPARING TRIIODOISOPHTHALAMIDE X-RAY CONTRAST MEDIA IOVERSOL
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The present invention relates to a method for producing an X-ray contrast agent ioversol. More specifically, the present invention relates to the method for manufacturing the X-ray contrast agent ioversol in which an inorganic base, chloride and the like are added to 5-(2-hydroxyacetamido)-N,Nandprime;-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide(chemical formula 9), followed by performing an N-alkylation reaction, thereby being able to easily separating and removing inorganic salts generated during reaction without ion exchange resin treatment while shortening an existing manufacturing time, and thus being able to minimize reaction impurities.COPYRIGHT KIPO 2020
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Paragraph 0043-0045
(2020/03/05)
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