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5-Fluoro-2-nitropyridine is a chemical compound characterized by the molecular formula C5H3FN2O2. It is a yellow solid known for its reactivity and is primarily utilized as a building block in the synthesis of pharmaceuticals and agrochemicals. 5-Fluoro-2-nitropyridine is also employed as an intermediate in the production of various organic compounds, with its fluoro and nitro functional groups being particularly valuable in organic synthesis. Due to its hazardous and toxic nature to the environment, it is crucial to handle 5-Fluoro-2-nitropyridine with care.

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  • 779345-37-8 Structure
  • Basic information

    1. Product Name: 5-Fluoro-2-nitropyridine
    2. Synonyms: Pyridine, 5-fluoro-2-nitro-
    3. CAS NO:779345-37-8
    4. Molecular Formula: C5H3FN2O2
    5. Molecular Weight: 142.09
    6. EINECS: N/A
    7. Product Categories: Fluorine series
    8. Mol File: 779345-37-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 245.05 °C at 760 mmHg
    3. Flash Point: 102.003 °C
    4. Appearance: /
    5. Density: 1.439 g/cm3
    6. Vapor Pressure: 0.046mmHg at 25°C
    7. Refractive Index: 1.538
    8. Storage Temp.: Inert atmosphere,Room Temperature
    9. Solubility: N/A
    10. PKA: -5.01±0.22(Predicted)
    11. CAS DataBase Reference: 5-Fluoro-2-nitropyridine(CAS DataBase Reference)
    12. NIST Chemistry Reference: 5-Fluoro-2-nitropyridine(779345-37-8)
    13. EPA Substance Registry System: 5-Fluoro-2-nitropyridine(779345-37-8)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 779345-37-8(Hazardous Substances Data)

779345-37-8 Usage

Uses

Used in Pharmaceutical Industry:
5-Fluoro-2-nitropyridine is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its presence of fluoro and nitro functional groups allows for the creation of diverse chemical structures, enhancing the pharmacological properties of the resulting compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Fluoro-2-nitropyridine serves as a key intermediate in the synthesis of pesticides and other agrochemicals. Its reactivity and functional groups enable the production of effective and targeted compounds for pest control and crop protection.
Used in Organic Synthesis:
5-Fluoro-2-nitropyridine is used as an intermediate in the production of various organic compounds. Its reactivity allows for the introduction of fluoro and nitro functional groups into organic molecules, which can significantly alter their properties and reactivity, leading to the development of new and improved materials.
Used in Research and Development:
5-Fluoro-2-nitropyridine is utilized in research and development settings to explore its potential applications and properties. Its unique structure and reactivity make it an interesting subject for scientific investigation, potentially leading to new discoveries and innovations in the fields of chemistry and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 779345-37-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,7,9,3,4 and 5 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 779345-37:
(8*7)+(7*7)+(6*9)+(5*3)+(4*4)+(3*5)+(2*3)+(1*7)=218
218 % 10 = 8
So 779345-37-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H3FN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H

779345-37-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Fluoro-2-nitropyridine

1.2 Other means of identification

Product number -
Other names Pyridine,5-fluoro-2-nitro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:779345-37-8 SDS

779345-37-8Upstream product

779345-37-8Relevant articles and documents

Heterocyclic Compound as CDK-HDAC Double-Channel Inhibitor

-

Paragraph 0141-0142, (2022/02/27)

The invention provides compounds of formula (I) as shown below, including their possible enantiomers and diastereomers, as well as pharmaceutically acceptable salts, hydrates or solvates thereof. The invention also provides pharmaceutical compositions of

Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design

O'Brien, Alistair,Andrews, Stephen P.,Baig, Asma H.,Bortolato, Andrea,Brown, Alastair J.H.,Brown, Giles A.,Brown, Sue H.,Christopher, John A.,Congreve, Miles,Cooke, Robert M.,De Graaf, Chris,Errey, James C.,Fieldhouse, Charlotte,Jazayeri, Ali,Marshall, Fiona H.,Mason, Jonathan S.,Mobarec, Juan Carlos,Okrasa, Krzysztof,Steele, Kelly N.,Southall, Stacey M.,Teobald, Iryna,Watson, Steve P.,Weir, Malcolm

supporting information, (2019/09/30)

A series of novel allosteric antagonists of the GLP-1 receptor (GLP-1R), exemplified by HTL26119, are described. SBDD approaches were employed to identify HTL26119, exploiting structural understanding of the allosteric binding site of the closely related Glucagon receptor (GCGR) (Jazayeri et al., 2016) and the homology relationships between GCGR and GLP-1R. The region around residue C3476.36b of the GLP-1R receptor represents a key difference from GCGR and was targeted for selectivity for GLP-1R.

TYK2 INHIBITORS AND USES THEREOF

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Paragraph 001083; 001084, (2015/09/28)

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

BICYCLIC INHIBITORS OF ALK

-

Page/Page column 158, (2012/08/07)

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein R1, X, Y, Z, A, B, G1, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

PROTEIN KINASE INHIBITORS

-

Page/Page column 7, (2010/07/04)

The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof which is useful in the treatment of cell proliferative diseases.

Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)- bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors

Bunnelle, William H.,Daanen, Jerome F.,Ryther, Keith B.,Schrimpf, Michael R.,Dart, Michael J.,Gelain, Arianna,Meyer, Michael D.,Frost, Jennifer M.,Anderson, David J.,Buckley, Michael,Curzon, Peter,Cao, Ying-Jun,Puttfarcken, Pamela,Searle, Xenia,Ji, Anguo,Putman, C. Brent,Surowy, Carol,Toma, Lucio,Barlocco, Daniela

, p. 3627 - 3644 (2008/02/11)

A series of exceptionally potent agonists at neuronal nicotinic acetylcholine receptors (nAChRs) has been investigated. Several N-(3-pyridinyl) derivatives of bridged bicyclic diamines exhibit double-digit-picomolar binding affinities for the α4β2 subtype, placing them with epibatidine among the most potent nAChR ligands described to date. Structure-activity studies have revealed that substitutions, particularly hydrophilic groups in the pyridine 5-position, differentially modulate the agonist activity at ganglionic vs central nAChR subtypes, so that improved subtype selectivity can be demonstrated in vitro. Analgesic efficacy has been achieved across a broad range of pain states, including rodent models of acute thermal nociception, persistent pain, and neuropathic allodynia. Unfortunately, the hydrophilic pyridine substituents that were shown to enhance agonist selectivity for central nAChRs in vitro tend to limit CNS penetration in vivo, so that analgesic efficacy with an improved therapeutic window was not realized with those compounds.

Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders

-

, (2008/06/13)

Disclosed are pyrrolopyridazine compounds, methods of preparing such compounds, and their use for the treatment of proliferative, inflammatory, and other disorders.

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