- Synthesis and anthelmintic activity of some novel (E)-2-methyl/propyl-4-(2-(substitutedbenzylidene)hydrazinyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines
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A series of some novel (E)-2-methyl/propyl-4-[(2-(substitutedbenzylidene)hydrazinyl]-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines was synthesized and characterized by adopting an appropriate synthetic scheme. The effect of electron withdrawing and
- Chitikina, Satya Sri,Buddiga, Praveen,Deb, Pran Kishore,Mailavaram, Raghu Prasad,Venugopala, Katharigatta N.,Nair, Anroop B.,Al-Jaidi, Bilal,Kar, Supratik
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p. 1600 - 1610
(2020/07/13)
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- Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication
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A structure-based virtual screening technique was applied to the study of the HCV NS3 helicase, with the aim to find novel inhibitors of the HCV replication. A library of ~450000 commercially available compounds was analysed in silico and 21 structures were selected for biological evaluation in the HCV replicon assay. One hit characterized by a substituted thieno-pyrimidine scaffold was found to inhibit the viral replication with an EC50value in the sub-micromolar range and a good selectivity index. Different series of novel thieno-pyrimidine derivatives were designed and synthesised; several new structures showed antiviral activity in the low or sub-micromolar range.
- Bassetto, Marcella,Leyssen, Pieter,Neyts, Johan,Yerukhimovich, Mark M.,Frick, David N.,Brancale, Andrea
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- Synthesis and adenosine receptor binding studies of some novel triazolothienopyrimidines
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A new series of 5-alkyl/aryl-8,9-dimethyl/8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine-3(2H)-thiones (4a-k) have been synthesized through a facile cyclization reaction of 4-hydrazino-2-alkyl/aryl-5,6-dimethyl/5,6,7,8-tetrahydr
- Raghu Prasad, Mailavaram,Raghuram Rao, Akkinepally,Shanthan Rao, Pamulaparthy,Rajan, Kombu Subramanian,Meena, Shanmugam,Madhavi, Kuchana
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p. 614 - 620
(2008/09/19)
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- Synthesis and Biological Activity of Tetrazolothienopyrimidines
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4-Hydrazinothienopyrimidines (VI) undergo cyclization with nitrous acid to give tetrazolothienopyrimidines (VII).The latter compounds have been screened for their analgesic and antiinflammatory activities.
- Shishoo, C. J.,Devani, M. B.,Karvekar, M. D.,Ullas, G. V.,Ananthan, S.,et al.
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p. 666 - 668
(2007/10/02)
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