- Preparation of diastereomerically pure immunologically active carbocyclic nor-muramyldipeptide analogues
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The preparation of diastereomerically pure immunologically active carbocyclic nor-muramyldipeptide analogues (1'R,2'R)-/(1'S,2'S)-N-[2-(2'-acetylaminocyclohexyloxy)acetyl]-L- alanyl-D-isoglutamine and (1'R,2'R)-/(1'S,2'S)-N-[2-(2'-acetylaminocyclohexyloxy)acetyl]-L- alanyl-D-glutamic acid is described. The title compounds were synthesized using two independent synthetic routes from racemic trans-2-azidocyclohexanol and (1R,2R)-/(1S,2S)-2-aminocyclohexanol, respectively.
- Kikelj,Kidric,Pristovisek,Pecar,Urleb,Krbavcic,Honig
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p. 5915 - 5932
(2007/10/02)
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- Diphosphonic acid compounds and use for calcium metabolism disorders
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The present invention provides compounds of the formula: STR1 The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them useful in treatment and prophylaxis of disorders of calcium metabolism.
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