Sc(OTf)3-Catalyzed [3 + 3] Cycloaddition of Cyclopropane 1,1-Diesters with Phthalazinium Dicyanomethanides
The Sc(OTf)3-catalyzed diastereoselective [3 + 3] cycloaddition of phthalazinium dicyanomethanides with cyclopropane 1,1-diesters proceeded smoothly under mild reaction conditions, affording a variety of 3,4-dihydro-1H-pyrido[2,1-a]phthalazine derivatives in up to 99% yields with excellent diastereoselectivities.
One-pot synthesis of phthalazines and pyridazino-aromatics: A novel strategy for substituted naphthalenes
A new one-pot strategy for the synthesis of phthalazines and pyridazino-aromatics starting from aromatic aldehydes has been developed. A variety of substituents ranging from electron withdrawing to donating is tolerated furnishing the desired 1,2-diazine in good to excellent yields. The products have been applied to the bidentate Lewis acid catalyzed inverse electron-demand Diels-Alder (IEDDA) reaction opening a novel two-step entry into substituted naphthalenes, such as Naproxen.
Kessler, Simon N.,Wegner, Hermann A.
supporting information; experimental part
p. 3268 - 3271
(2012/08/28)
PHTHALAZINE DERIVATIVES FROM AROMATIC ALDAZINES
A Lewis acid mediated synthesis of phthalazine derivatives II and III from aromatic aldazines I is reported.
Robev, Stefan K.
p. 345 - 348
(2007/10/02)
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