- An Electrochemical Way to Generate Amphiphiles from Hydrazones for the Synthesis of 1,2,4-Triazole Scaffold Cyclic Compounds
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An electro-oxidative cyclization pathway in which hydrazones are selected as starting materials to generate amphiphiles by reacting with benzylamines and benzamides was reported. This strategy successfully prepared a series of 1,2,4-triazoles in satisfact
- Li, Wangyu,Liang, Xiao,Pan, Yuanjiang,Wang, Dungai,Xiong, Mingteng,Zhu, Heping
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- Direct Access to 1,3,5-Trisubstituted 1 H -1,2,4-Triazoles from N -Phenylbenzamidines via Copper-Catalyzed Diamination of Aryl Nitriles
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A copper-catalyzed formation of C-N/N-N bonds using N-phenylbenzamidines with aryl nitriles has been developed and affords a route to 1,3,5-trisubstituted 1H-1,2,4-triazoles in moderate to excellent yields. The method is operationally simple and environme
- Zhang, Lutao,Tang, Dong,Gao, Jing,Wang, Jing,Wu, Ping,Meng, Xu,Chen, Baohua
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p. 3924 - 3930
(2016/11/11)
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- On the Reaction of Isocyanides with Nitrile Imines
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Four competing reactions have been found to occur when nitrile imines 2 are generated from 1 in the presence of isocyanides 3.The products obtained include i) 1,2,3-triazolium salts 6, ii) 1,2,4-triazolium salts 8, iii) dihydrotriazolyl-substituted pyrazolamines 11, and iv) unstable 1,2-diazetimine derivatives 12 which in turn give carbodiimides 13, nitriles 14, quinoxalinamines 15, and possibly 1,2,4-triazoles 16 (after addition of 2).The proportions, in particular those of 6,8, and 11, depend on the reaction conditions; thus, triethylamine used in excess can oppress the formation of 6 in favour of 8 and 11. - The structure of 11 has been elucidated by means of X-ray diffraction analyses of 11a and c. - Key Words: Isocyanides / Nitrile imines / Triazolium salts / Pyrazoles / 1,2-Diazet-3-imines
- Moderhack, Dietrich,Lorke, Michael,Ernst, Ludger,Schomburg, Dietmar
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p. 1633 - 1640
(2007/10/02)
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- Rearrangement Reactions of 1,3,6-Triaryl-1,4-dihydro-s-tetrazines leading to 2,4-Diarylquinazolines, 1-Anilino-3,5-diaryl-1H-1,2,4-triazoles, 1,3,5-Triaryl-1H-1,2,4-triazoles, and 2,5-Diaryl-1H-1,3,4-oxadiazoles. X-ray Structure Determination of 6-Isopropyl-2,4-diphenylquinazoline
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1,3,6-Triaryl-1,4-dihydro-s-tetrazines (2c-g) rearrange on heating at ca. 200 deg C to 2,4-diarylquinazolines (for which an X-ray determination was carried out on the 6-isopropyl compound) and 1-anilino-3,5-diaryl-1H-1,2,4-triazoles as major products.Hydrolysis in chloroform solution of the title compounds (2) and their 1-alkyl analogues gives rise to 1-aryl (or alkyl)-3,5-diaryl-1H-1,2,4-triazoles and 2,5-diaryl-1,3,4-oxadiazoles.
- Hunter, Daniel,Neilson, Douglas G.,Weakley, Timothy J.R.
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p. 2709 - 2712
(2007/10/02)
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- 1H-1,2,4-Triazole 2-oxide from O-benzoyl derivatives of N-Substituted benzamidoximes and benzonitrile oxide
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Treatment of the readily prepared O-benzoyl derivatives of N-substituted benzamidoximes with benzonitrile oxide gave 1H-1,2,4-triazole 2-oxides.
- Foti, Francesco,Grassi, Giovanni,Risitano, Francesco,Caruso, Francesco
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p. 3048 - 3054
(2007/10/02)
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