- USE OF CYCLOOXYGENASE-2 INHIBITORS FOR THE TREATMENT OF DEPRESSIVE DISORDERS
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The invention concerns the use of compounds of formula (I), (II) and (III): which are COX-2 (cyclooxygenase-2) inhibitors, and pharmaceutically acceptable salts or solvates thereof, for the treatment of depressive disorders in combination with an effective amount of a second component which is a selective serotonin reuptake inhibitor.
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Page/Page column 31-32
(2008/06/13)
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- Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors
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GW406381 (8), currently undergoing clinical evaluation for the treatment of inflammatory pain is a member of a novel series of 2,3-diaryl-pyrazolo[1,5-b] pyridazine based cyclooxygenase-2 (COX-2) inhibitors, which have been shown to be highly potent and selective. Several examples of the series, in addition to possessing favourable pharmacokinetic profiles and analgesic activity in vivo, have also demonstrated relatively high brain penetration in the rat compared with the clinically available compounds, which may ultimately prove beneficial in the treatment of pain.
- Beswick, Paul,Bingham, Sharon,Bountra, Chas,Brown, Terry,Browning, Kerry,Campbell, Ian,Chessell, Iain,Clayton, Nick,Collins, Sue,Corfield, John,Guntrip, Stephen,Haslam, Claudine,Lambeth, Paul,Lucas, Fiona,Mathews, Neil,Murkit, Graham,Naylor, Alan,Pegg, Neil,Pickup, Elizabeth,Player, Hazel,Price, Helen,Stevens, Alexander,Stratton, Sharon,Wiseman, Joanne
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p. 5445 - 5448
(2007/10/03)
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- 2,3-Diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase 2(COX-2) inhibitors
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The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0is halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy substituted by one or more fluorine atoms, or O(C
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