CHEMICAL REACTIONS OF SILYL-SUBSTITUTED HYDROXAMIC ACIDS
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Feoktistov, A. E.,Orlov, G. I.,Kozyukov, V. P.,Mironov, V. F.
p. 780 - 783
(2007/10/02)
Synthesis, hydrolytic reactivity, and anticancer evaluation of N-and O-triorganosilylated compounds as new types of potential prodrugs
N- and O-Triorganosilylated compounds related to various anticancer agents were synthesized for evaluation as potential anticancer prodrugs. 1H-NMR and UV kinetic measurements of hydrolytic desilylation were used to correlate relative rates of structural unmasking with steric bulk about the silicon reaction center. The tert-butyldimethylsilyl ester of chlorambucil and a number of O-triorganosilylated carbamate derivatives of nor-nitrogen mustard showed significant activity against P-388 lymphocytic leukemia in mice.
Chiu,Chang,Ozkan,Zon,Fichter,Phillips
p. 542 - 551
(2007/10/02)
Organosilicon(IV) Derivatives of Hydroxamic Acids and N-Arylamidoximes
Mono-(triorganosilyl)hydroxamates(III), mono-(diorganochlorosilyl)hydroxamates(IV), mono-(triorganosilyl)-N-arylamidoximes(V), mono--N-arylamidoximes(VI) and bis-(trimethylsilyl) hydroxamates(VII) have been prepared and characterized on the basis of molecular weight, IR and PMR data.
Narula, C. K.,Gupta, V. D.
p. 1095 - 1098
(2007/10/02)
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