Synthesis and antitumoractivity of liquiritigenin thiosemicarbazone derivatives
In an attempt to develop potent and selective antitumor agents,a series of liquiritigenin thio-semicarbazone derivatives were designed and synthesized. The cytotoxicities of these compounds were evaluated in vitro against K562,DU-145,SGC-7901,HCT-116 and Hela cell lines. The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward K562 and DU-145 cells. From the structureeactivity relationships we may conclude that the introduction of a thiosemicarbazone functional group at the 4-position in the skeleton of liquiritigenin is associated with an increase in cytotoxicity.
Hu, Kun,Yang, Ze-Hua,Pan, Sha-Sha,Xu, Hua-Jin,Ren, Jie
experimental part
p. 3453 - 3458
(2010/08/13)
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